An interventional study of Instruction on analgesic use for pain relief (acetaminophen and NSAIDs) and Neuromuscular exercise in Osteoarthritis, Knee, sponsored by University of Southern Denmark. Completed at 1 site in Denmark. Open to participants aged 40 Years to 70 Years. Per ClinicalTrials.gov, last updated 2016-08-03.
Sponsored by University of Southern Denmark · Not applicable, Interventional, and Treatment
The purpose of this study is to compare the effects of neuromuscular exercise and analgesic use on knee joint load, in patients with mild to moderate knee osteoarthritis (OA).
It is expected that the two groups will receive equipotent pain relieving effect, despite this, the investigators expect a between group difference in knee joint load, and the exercise group will have a reduction in knee joint load.
4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.
This study's enrollment of 93 is above the median of 70 across 3,440 interventional studies indexed under Osteoarthritis.
Browse Osteoarthritis studies →University of Southern Denmark is the lead sponsor of 327 studies on the registry; 45 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
NEuroMuscular EXercise
Other: Neuromuscular exercise
PHARMAcological pain relief
Drug: Instruction on analgesic use for pain relief (acetaminophen and NSAIDs)
The PHARMA group receives instruction, by video and pamphlet, on how to best use acetaminophen and NSAID as pain management for knee OA.
Also known as: Acetaminophen, Non-Steroid Anti-Inflamatoric Drug:, Ibuprofen, Acetylsalicylic acid, Celecoxib, Dexibuprofen, Etoricoxib, Lornoxicam, Meloxicam, Diclofenac, Etodolac, Indomethacin, Nabumetone, Naproxen, Tenoxicam, Tiaprofenic acid, Dexketoprofen
The exercise group receives 1 hour of supervised neuromuscular exercise two times a week for 8 weeks. Supervision is conducted by physiotherapists specially trained in using neuromuscular exercise and its principles.
Also known as: Exercise, Stability, Alignment, Functional
Change from baseline in 1st peak RMS (root mean square) Knee Index.
1st peak RMS Knee Index, is combined of the moments of the 3 planes working over the the knee; flexion, adduction and internal rotation moments. Measured with the Vicon system. 1st peak RMS knee moment = √(Kflex. moment2 + Kadd. moment2 + Kint.rot. moment2 )/3
Time frame: Baseline and post intervention (8 weeks)
Change from baseline in 1st peak Knee adduction moment
Time frame: Baseline and post intervention (8 weeks)
Change from baseline in the KOOS (Knee injury and Osteoarthritis Outcome Score) questionnaire
Time frame: Baseline and post intervention (8 weeks)
Change from baseline in Maximum number of one-leg rises from stool test
This test evaluates maximal performance and muscle strength in the lower extremity
Time frame: Baseline and post intervention (8 weeks)
Change from baseline in Maximum number of knee-bendings in 30s test
This test evaluates the ability to perform fast changes between eccentric and concentric muscle force over the knee joint
Time frame: Baseline and post intervention (8 weeks)
Change from baseline in One-leg hop for distance test
The test mimics sporting activities and demands muscle explosivety, balance and functional stability of the knee
Time frame: Baseline and post intervention (8 weeks)
This study is completed, as verified in Aug 2016. You cannot join it, but the record below documents what was studied.
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University of Southern Denmark