An observational study in Periprosthetic Bone Loss in Total Knee Replacement, sponsored by National Taiwan University Hospital. Status unknown at 1 site in Taiwan. Open to female participants aged 50 Years to 70 Years. Per ClinicalTrials.gov, last updated 2012-06-13.
Sponsored by National Taiwan University Hospital · Observational
The investigators hypothesized that the microarchitecture of bone influence the degree of periprosthetic bone loss after total knee arthroplasty surgery. The investigators collected the bone fragment at the distal femur while performing total knee replacement and take quantitative radiography analysis . Before and after the surgery(6 month ,12 month) , the investigators check the BMD at identical location of the distal femur by using dual energy absorptiometry. The investigators will use linear regression to evaluate the relationship between the microarchitecture and the degree of bone loss.
470 studies on the registry are indexed under Bone Diseases, Metabolic; 71 are open to participants now.
This study's planned enrollment of 50 is below the median of 81 across 103 observational studies indexed under Bone Diseases, Metabolic.
Browse Bone Diseases, Metabolic studies →National Taiwan University Hospital is the lead sponsor of 2,563 studies on the registry; 569 are open to participants now.
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the patients who are indicated for total knee arthroplasty and are post menopausal women. The patients who had history of immune disease , fracture of the femur and end stage of renal disease will be excluded
Exclusion Criteria:
the woman who are indicated for TKR and are post menopausal will be recruited in this study. We will excluded the patients who had immune disease ,previous fracture of femur and end stage of renal disease
Radiation: dual energy x-ray absorptiometry
before the surgery of total knee arthroplasty and after the surgery 6 months and 12 months
change in bone mineral density
Use dual energy x-ray absorptiometry to detect to BMD at the distal femur
Time frame: before the surgery and after the sugery (6month ,12month)
This study is status unknown, as verified in Jun 2012. You cannot join it, but the record below documents what was studied.
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National Taiwan University Hospital