An interventional study of Supervised Resistance and Core Stabilization Exercise Program in Low Bone Mineral Density and Muscle Oxygenation, sponsored by Emine Merve Ersever. Not yet recruiting. Open to male participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-26.
Sponsored by Emine Merve Ersever · Not applicable, Interventional, and Treatment
This prospective, single-group interventional pilot study will evaluate the effects of a 12-week resistance and core stabilization exercise program on bone mineral density and resting muscle oxygenation in male military test pilots with low baseline bone mineral density. Participants will complete a supervised exercise program five days per week for 12 weeks while continuing their routine flight duties. Bone mineral density will be assessed using dual-energy X-ray absorptiometry, and resting muscle oxygenation will be evaluated in the vastus lateralis and rectus abdominis using near-infrared spectroscopy before and after the intervention. The study aims to characterize preliminary skeletal and muscle oxygenation responses to structured exercise in this specialized aviation population.
661 studies on the registry are indexed under Bone Diseases, Metabolic; 93 are open to participants now.
This study's planned enrollment of 10 is below the median of 60 across 509 interventional studies indexed under Bone Diseases, Metabolic.
Browse Bone Diseases, Metabolic studies →Emine Merve Ersever is the lead sponsor of 2 studies on the registry; 2 are open to participants now.
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Male military test pilots with previous military aviation experience Low bone mineral density identified by dual-energy X-ray absorptiometry (DXA) Regular participation in flight duties Medical fitness to participate in regular exercise training Willingness to participate in the 12-week supervised resistance and core stabilization exercise program Ability to provide written
Exclusion Criteria:
Acute musculoskeletal injury Recent orthopedic surgery Neurological disorder Cardiovascular disease Any medical condition that limits participation in physical exercise Subcutaneous adipose tissue thickness greater than 17.5 mm at the NIRS measurement site
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will complete a 12-week supervised resistance and core stabilization exercise program, performed five days per week for approximately 120 minutes per session. The program will progress through three phases: adaptation (weeks 1-4, approximately 60% of one-repetition maximum), strength development (weeks 5-8, 70-75% of one-repetition maximum), and high-load neuromuscular control (weeks 9-12, 80-85% of one-repetition maximum). The intervention will include multi-joint lower-extremity exercises such as squats and deadlifts, core stabilization exercises including planks, side planks, bird-dog, dead bug, and posterior pelvic tilt, and posterior-chain exercises such as lunges, hip thrusts, and back extensions. All sessions will be supervised by a physiotherapist, and training loads will be adjusted according to participant performance and tolerance
Behavioral: Supervised Resistance and Core Stabilization Exercise Program
Participants will undergo a 12-week physiotherapist-supervised resistance and core stabilization exercise program performed five days per week for approximately 120 minutes per session. The program will progress through three phases: adaptation (weeks 1-4, approximately 60% of one-repetition maximum \[1RM\]), strength development (weeks 5-8, 70-75% 1RM), and high-load neuromuscular control (weeks 9-12, 80-85% 1RM). The intervention will include multi-joint lower-extremity exercises (squat and deadlift), core stabilization exercises (plank, side plank, bird-dog, dead bug, and posterior pelvic tilt), and posterior-chain exercises (lunges, hip thrusts, and back extensions). Exercise tempo and rest intervals will be standardized, and training loads will be individually adjusted according to participant performance and tolerance
Change in Bone Mineral Density
BMD will be assessed by DXA at lumbar spine and proximal femoral sites and recorded in g/cm². Change from baseline to 12 weeks will be evaluated. Time Frame: Baseline and 12 weeks
Time frame: Baseline and 12 weeks
Change in Resting Muscle Oxygen Saturation (SmO₂)
Resting muscle oxygen saturation will be measured using NIRS in the vastus lateralis and rectus abdominis and reported as percentage (%). Change from baseline to 12 weeks will be evaluated.
Time frame: Baseline and 12 weeks
Change in Total Haemoglobin (tHb)
Resting total haemoglobin concentration will be measured using NIRS in the vastus lateralis and rectus abdominis and reported in μM. Change from baseline to 12 weeks will be evaluated.
Time frame: Baseline and 12 weeks
Change in Oxyhaemoglobin (O₂Hb)
Resting oxyhaemoglobin concentration will be measured using NIRS in the vastus lateralis and rectus abdominis and reported in μM. Change from baseline to 12 weeks will be evaluated.
Time frame: Baseline and 12 weeks
Change in Deoxyhaemoglobin (HHb)
Resting deoxyhaemoglobin concentration will be measured using NIRS in the vastus lateralis and rectus abdominis and reported in μM. Change from baseline to 12 weeks will be evaluated.
Time frame: Baseline and 12 weeks
Change in Haemoglobin Difference (HbDiff)
Resting haemoglobin difference will be derived from NIRS measurements in the vastus lateralis and rectus abdominis and reported in μM. Change from baseline to 12 weeks will be evaluated.
Time frame: Baseline and 12 weeks
No study locations are listed for this record.
Plan to share: No
Start is estimated for Sep 2026; primary completion for Dec 2026, 3 months later.
Of 161 non-industry interventional studies with no phase under Bone Diseases, Metabolic, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 38. This study's planned 3 months is below that.
Counting every sponsor, half of 177 studies reached it within 22 months; a quarter within 10 and three quarters within 38.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Emine Merve Ersever