An interventional study of Transcranial Direct Current Stimulation (tDCS) in Corneal Pain, Chronic Pain and Neuropathic Pain, sponsored by Spaulding Rehabilitation Hospital. Completed at 1 site in United States. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-04-24.
Sponsored by Spaulding Rehabilitation Hospital · Not applicable, Interventional, and Basic science
In this study the investigators aim to examine the effects of Transcranial Direct Current Stimulation (tDCS) on pain levels as well as the changes in cognitive (thought) processing in individuals with chronic pain of the cornea -- and also compared with healthy controls.
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Additional Inclusion Criteria for Subjects with Chronic Corneal Pain:
Exclusion Criteria (for all subjects):
Contraindications to tDCS
Subjects will undergo 20 minutes of active tDCS stimulation.
Device: Transcranial Direct Current Stimulation (tDCS)
Subjects will undergo 20 minutes of sham tDCS stimulation.
Device: Transcranial Direct Current Stimulation (tDCS)
Subjects will undergo 2 sessions of 20 minutes of tDCS stimulation (either active or sham)in a randomized order - each session will be separated by at least one week to prevent carry-over effects.
Also known as: 1x1 direct current stimulator; Soterix Medical
Changes in pain scales
We will measure changes in the visual analogue scale (VAS) for pain, and also measure pain threshold (using an algometer) before and after each stimulation session. We will compare the measurements from before stimulation to after stimulation, in each scheduled session, as this study is measuring the effects of a single session of tDCS.
Time frame: Measured for approximately 2 weeks
Changes in EEG measurements
We will measure changes in event related potentials (ex. P300, mismatch negativity) recorded via electroencephalography (EEG) before and after each stimulation session. We will compare the measurements from before stimulation to after stimulation, in each scheduled session, as this study is measuring the effects of a single session of tDCS.
Time frame: Measured for approximately 2 weeks
This study is completed, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.
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Spaulding Rehabilitation Hospital