An observational study in Breast Cancer, sponsored by Institute of Cancer Research, United Kingdom. Completed at 1 site in United Kingdom. Open to female participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2016-06-15.
Sponsored by Institute of Cancer Research, United Kingdom · Observational
Objective: To determine the accuracy of multi-functional magnetic resonance (MR) in detecting, localising and characterising satellite lesions in relation to an index breast tumour in order to improve definition of clinical target volume after local excision.
Hypothesis: Pre-operative multi-functional MR has high sensitivity and specificity for localising unsuspected multifocal and multicentric lesions in women diagnosed with early breast cancer.
12,544 studies on the registry are indexed under Breast Neoplasms; 2,892 are open to participants now.
This study's enrollment of 16 is below the median of 184 across 2,642 observational studies indexed under Breast Neoplasms.
Browse Breast Neoplasms studies →Institute of Cancer Research, United Kingdom is the lead sponsor of 111 studies on the registry; 27 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Women with confirmed breast cancer
Exclusion Criteria:
Sensitivity of MR techniques in detecting histopathologically-identified multifocal and multicentric lesions
Sensitivity of the MR technique in detecting histopathologically-identified multifocal/centric pre-invasive/invasive disease will be calculated (with 95% confidence intervals)from positive or negative correlates.
Time frame: 4 years
Closeness of agreement between MR techniques and histopathology in localising satellite lesions relative to the index tumour.
Distance \& distribution of lesions from reference tumour will be plotted and correlated with distances and signal characteristics seen on multifunctional MR. Pre-op MRI volume will be plotted against histopathological dimensions and examined for agreement between the two methods. Paired Wilcoxon signed-rank tests will be used to test for systematic differences between MRI and pathology measurements.
Time frame: 4 years
This study is completed, as verified in Jun 2016. You cannot join it, but the record below documents what was studied.
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Institute of Cancer Research, United Kingdom