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Active, not recruitingNCT01555411ACE1950Updated May 8, 2024

Akershus Cardiac Examination (ACE) 1950 Study

An observational study in Atrial Fibrillation, Heart Failure and Mild Cognitive Impairment, sponsored by Vestre Viken Hospital Trust. Active, not recruiting at 2 sites in Norway. Open to participants aged 62 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-05-08.

Sponsored by Vestre Viken Hospital Trust · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
3,706
Ages
62 Years to 65 Years
Sex
All
01

Study summary

Akershus Cardiac Examination (ACE) 1950 Study is a large, observational, prospective, longitudinal, population-based cohort study. The overall aim is to establish an extensive cardio- and cerebrovascular age cohort of elderly subjects for various longitudinal long-term follow-up studies of cardiovascular and cerebrovascular disease.

Read the detailed description

Design: The Akershus Cardiac Examination (ACE) 1950 Study is a population-based, prospective, cerebro- and cardiovascular age-cohort study of all men and women born in 1950 in Akershus County, Norway.

Time schedule: Study inclusion and baseline examinations took place in the period September 2012 - May 2015.

Current status: 10-year follow-up examinations of all participants are undertaken in 2023-2025, and sub-studies are ongoing.

02

Conditions studied

  • Atrial Fibrillation
  • Heart Failure
  • Mild Cognitive Impairment
  • Cardiovascular Diseases
  • Cerebrovascular Disorders

Keywords

  • Cardiovascular epidemiology
  • Prospective, observational cohort study
  • Biomarkers
  • Cardio- and cerebrovascular imaging
03

In context

Cerebrovascular Disorders

374 studies on the registry are indexed under Cerebrovascular Disorders; 129 are open to participants now.

This study's planned enrollment of 3,706 is above the median of 443 across 135 observational studies indexed under Cerebrovascular Disorders.

Browse Cerebrovascular Disorders studies →

Lead sponsor

Vestre Viken Hospital Trust is the lead sponsor of 51 studies on the registry; 22 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
62 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Residents of Akershus County, Norway, born in 1950.

Eligibility criteria

Inclusion Criteria:

  • Resident in Akershus County (as per October 2011, prior to study invitation)
  • Born in the year of 1950
  • Ability to consent to participation
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
3,706 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • No treatment
06

What researchers measure

Primary outcomes

  1. Outcomes related to CVD and CV-associated conditions

    Time frame: Maximum 35 years

Secondary outcomes

  1. Specific CV endpoints; e.g. acute myocardial infarction, heart failure, atrial fibrillation, etc.

    Time frame: Maximum 35 years

  2. Specific CV-associated conditions, including renal, cerebrovascular, pulmonary, etc.

    Time frame: Maximum 35 years

  3. Specific clinical phenotypes; e.g. myocardial and arterial structure and function, lung function, etc.

    Time frame: Maximum 35 years

Other outcomes

  1. Impact of left atrial size and function measurements by echocardiography on stroke risk in an 62-65-year-old cohort

    Time frame: Within 35 years

  2. Relation between cognitive function and sub-clinical CVD in a 62-65-year-old Norwegian population cohort

    Time frame: Maximum 35 years

07

Study locations

2 sites
  • Akershus University Hospital
    Lørenskog, Akershus 1478, Norway
  • Vestre Viken HT, Baerum Hospital, Department of Medical Research
    Sandvika, Akershus 3004, Norway
08

References and documents

Publications

  • Berge T, Vigen T, Pervez MO, Ihle-Hansen H, Lyngbakken MN, Omland T, Smith P, Steine K, Rosjo H, Tveit A; ACE 1950 Study Group. Heart and Brain Interactions--the Akershus Cardiac Examination (ACE) 1950 Study Design. Scand Cardiovasc J. 2015;49(6):308-15. doi: 10.3109/14017431.2015.1086813. Epub 2015 Sep 12. PubMed 26364744 ↗
  • Ihle-Hansen H, Vigen T, Berge T, Einvik G, Aarsland D, Ronning OM, Thommessen B, Rosjo H, Tveit A, Ihle-Hansen H. Montreal Cognitive Assessment in a 63- to 65-year-old Norwegian Cohort from the General Population: Data from the Akershus Cardiac Examination 1950 Study. Dement Geriatr Cogn Dis Extra. 2017 Sep 28;7(3):318-327. doi: 10.1159/000480496. eCollection 2017 Sep-Dec. PubMed 29118784 ↗
  • Berge T, Brynildsen J, Larssen HKN, Onarheim S, Jenssen GR, Ihle-Hansen H, Christophersen IE, Myrstad M, Rosjo H, Smith P, Tveit A. Systematic screening for atrial fibrillation in a 65-year-old population with risk factors for stroke: data from the Akershus Cardiac Examination 1950 study. Europace. 2018 Nov 1;20(FI_3):f299-f305. doi: 10.1093/europace/eux293. PubMed 29095966 ↗
  • Berge T, Lyngbakken MN, Ihle-Hansen H, Brynildsen J, Pervez MO, Aagaard EN, Vigen T, Kvisvik B, Christophersen IE, Steine K, Omland T, Smith P, Rosjo H, Tveit A. Prevalence of atrial fibrillation and cardiovascular risk factors in a 63-65 years old general population cohort: the Akershus Cardiac Examination (ACE) 1950 Study. BMJ Open. 2018 Aug 1;8(7):e021704. doi: 10.1136/bmjopen-2018-021704. PubMed 30068617 ↗
  • Ihle-Hansen H, Vigen T, Ihle-Hansen H, Ronning OM, Berge T, Thommessen B, Lyngbakken MN, Orstad EB, Enger S, Nygard S, Rosjo H, Tveit A. Prevalence of Carotid Plaque in a 63- to 65-Year-Old Norwegian Cohort From the General Population: The ACE (Akershus Cardiac Examination) 1950 Study. J Am Heart Assoc. 2018 May 8;7(10):e008562. doi: 10.1161/JAHA.118.008562. PubMed 29739796 ↗
  • Chandra A, Rosjo H, Eide IA, Vigen T, Ihle-Hansen H, Orstad EB, Ronning OM, Lyngbakken MN, Berge T, Schmidt EB, Omland T, Tveit A, Svensson M. Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study. Eur J Nutr. 2020 Jun;59(4):1505-1515. doi: 10.1007/s00394-019-02007-3. Epub 2019 May 23. PubMed 31123865 ↗
  • Vigen T, Ihle-Hansen H, Lyngbakken MN, Berge T, Thommessen B, Ihle-Hansen H, Orstad EB, Enger S, Ariansen I, Rosjo H, Tveit A, Ronning OM. Blood pressure at age 40 predicts carotid atherosclerosis two decades later: data from the Akershus Cardiac Examination 1950 Study. J Hypertens. 2019 Oct;37(10):1982-1990. doi: 10.1097/HJH.0000000000002131. PubMed 31116158 ↗
  • Ihle-Hansen H, Vigen T, Berge T, Hagberg G, Engedal K, Ronning OM, Thommessen B, Lyngbakken MN, Nygard S, Rosjo H, Tveit A, Ihle-Hansen H. Carotid Atherosclerosis and Cognitive Function in a General Population Aged 63-65 Years: Data from the Akershus Cardiac Examination (ACE) 1950 Study. J Alzheimers Dis. 2019;70(4):1041-1049. doi: 10.3233/JAD-190327. PubMed 31306128 ↗
  • Aagaard EN, Kvisvik B, Pervez MO, Lyngbakken MN, Berge T, Enger S, Orstad EB, Smith P, Omland T, Tveit A, Rosjo H, Steine K. Left ventricular mechanical dispersion in a general population: Data from the Akershus Cardiac Examination 1950 study. Eur Heart J Cardiovasc Imaging. 2020 Feb 1;21(2):183-190. doi: 10.1093/ehjci/jez210. PubMed 31504360 ↗
  • Vigen T, Ihle-Hansen H, Lyngbakken MN, Berge T, Thommessen B, Ihle-Hansen H, Orstad EB, Enger S, Rosjo H, Tveit A, Ronning OM. Carotid Atherosclerosis is Associated with Middle Cerebral Artery Pulsatility Index. J Neuroimaging. 2020 Mar;30(2):233-239. doi: 10.1111/jon.12684. Epub 2019 Dec 30. PubMed 31889363 ↗
  • Ronningen PS, Berge T, Solberg MG, Enger S, Nygard S, Pervez MO, Orstad EB, Kvisvik B, Aagaard EN, Rosjo H, Tveit A, Steine K. Sex differences and higher upper normal limits for left atrial end-systolic volume in individuals in their mid-60s: data from the ACE 1950 Study. Eur Heart J Cardiovasc Imaging. 2020 May 1;21(5):501-507. doi: 10.1093/ehjci/jeaa004. PubMed 32031593 ↗
  • Lyngbakken MN, Aagaard EN, Kvisvik B, Berge T, Pervez MO, Brynildsen J, Tveit A, Steine K, Rosjo H, Omland T. Cardiac Troponin I and T Are Associated with Left Ventricular Function and Structure: Data from the Akershus Cardiac Examination 1950 Study. Clin Chem. 2020 Apr 1;66(4):567-578. doi: 10.1093/clinchem/hvaa023. PubMed 32227098 ↗
  • Chandra A, Rosjo H, Svensson M, Vigen T, Ihle-Hansen H, Orstad EB, Ronning OM, Lyngbakken MN, Nygard S, Berge T, Schmidt EB, Omland T, Tveit A, Eide IA. Plasma linoleic acid levels and cardiovascular risk factors: results from the Norwegian ACE 1950 Study. Eur J Clin Nutr. 2020 Dec;74(12):1707-1717. doi: 10.1038/s41430-020-0641-4. Epub 2020 Apr 27. PubMed 32341488 ↗
  • Chandra A, Lyngbakken MN, Eide IA, Rosjo H, Vigen T, Ihle-Hansen H, Orstad EB, Ronning OM, Berge T, Schmidt EB, Tveit A, Omland T, Svensson M. Plasma Trans Fatty Acid Levels, Cardiovascular Risk Factors and Lifestyle: Results from the Akershus Cardiac Examination 1950 Study. Nutrients. 2020 May 14;12(5):1419. doi: 10.3390/nu12051419. PubMed 32423040 ↗
  • Lyngbakken MN, Kvisvik B, Aagaard EN, Berge T, Pervez MO, Brynildsen J, Tveit A, Steine K, Rosjo H, Omland T. B-Type Natriuretic Peptide Is Associated with Indices of Left Ventricular Dysfunction in Healthy Subjects from the General Population: The Akershus Cardiac Examination 1950 Study. Clin Chem. 2021 Jan 8;67(1):204-215. doi: 10.1093/clinchem/hvaa257. PubMed 33279958 ↗
  • Lyngbakken MN, Vigen T, Ihle-Hansen H, Brynildsen J, Berge T, Ronning OM, Tveit A, Rosjo H, Omland T. Cardiac troponin I measured with a very high sensitivity assay predicts subclinical carotid atherosclerosis: The Akershus Cardiac Examination 1950 Study. Clin Biochem. 2021 Jul;93:59-65. doi: 10.1016/j.clinbiochem.2021.04.005. Epub 2021 Apr 20. PubMed 33861986 ↗
  • Myhre PL, Lyngbakken MN, Berge T, Roysland R, Aagaard EN, Pervez O, Kvisvik B, Brynildsen J, Norseth J, Tveit A, Steine K, Omland T, Rosjo H. Diagnostic Thresholds for Pre-Diabetes Mellitus and Diabetes Mellitus and Subclinical Cardiac Disease in the General Population: Data From the ACE 1950 Study. J Am Heart Assoc. 2021 Jun;10(11):e020447. doi: 10.1161/JAHA.120.020447. Epub 2021 May 17. PubMed 33998259 ↗
  • Myhre PL, Heck SL, Skranes JB, Prebensen C, Jonassen CM, Berge T, Mecinaj A, Melles W, Einvik G, Ingul CB, Tveit A, Berdal JE, Rosjo H, Lyngbakken MN, Omland T. Cardiac pathology 6 months after hospitalization for COVID-19 and association with the acute disease severity. Am Heart J. 2021 Dec;242:61-70. doi: 10.1016/j.ahj.2021.08.001. Epub 2021 Aug 13. PubMed 34400140 ↗
  • Caspersen NF, Soyseth V, Lyngbakken MN, Berge T, Ariansen I, Tveit A, Rosjo H, Einvik G. Treatable Traits in Misdiagnosed Chronic Obstructive Pulmonary Disease: Data from the Akershus Cardiac Examination 1950 Study. Chronic Obstr Pulm Dis. 2022 Apr 29;9(2):165-180. doi: 10.15326/jcopdf.2021.0265. PubMed 35158418 ↗
  • Ronningen PS, Berge T, Solberg MG, Enger S, Pervez MO, Orstad EB, Kvisvik B, Aagaard EN, Lyngbakken MN, Ariansen I, Rosjo H, Steine K, Tveit A. Impact of Blood Pressure in the Early 40s on Left Atrial Volumes in the Mid-60s: Data From the ACE 1950 Study. J Am Heart Assoc. 2022 Jun 7;11(11):e023738. doi: 10.1161/JAHA.121.023738. Epub 2022 May 27. PubMed 35621203 ↗
  • Aagaard EN, Lyngbakken MN, Kvisvik B, Berge T, Pervez MO, Ariansen I, Tveit A, Steine K, Rosjo H, Omland T. Associations between cardiovascular risk factors, biomarkers, and left ventricular mechanical dispersion: insights from the ACE 1950 Study. Eur Heart J Open. 2022 Feb 12;2(2):oeac006. doi: 10.1093/ehjopen/oeac006. eCollection 2022 Mar. PubMed 35919126 ↗
  • Lyngbakken MN, Kvisvik B, Berge T, Pervez MO, Aagaard EN, Ariansen I, Omland T, Tveit A, Steine K, Rosjo H. Serial blood pressure measurements, left ventricular remodelling and cardiovascular outcomes. Eur J Clin Invest. 2023 Jan;53(1):e13876. doi: 10.1111/eci.13876. Epub 2022 Sep 24. PubMed 36120822 ↗
  • Lyngbakken MN, Ronningen PS, Solberg MG, Berge T, Brynildsen J, Aagaard EN, Kvisvik B, Rosjo H, Steine K, Tveit A, Omland T. Prediction of incident atrial fibrillation with cardiac biomarkers and left atrial volumes. Heart. 2023 Feb 14;109(5):356-363. doi: 10.1136/heartjnl-2022-321608. PubMed 36261282 ↗
  • Walle-Hansen MM, Berge T, Vigen T, Myrstad M, Hagberg G, Ihle-Hansen H, Sandset EC, Thommessen B, Ariansen IKH, Lyngbakken MN, Rosjo H, Ronning OM, Tveit A, Ihle-Hansen H. Systolic blood pressure at age 40 and cognitive function 25 years later: the Akershus Cardiac Examination (ACE) 1950 Study. J Hypertens. 2023 Jan 1;41(1):132-139. doi: 10.1097/HJH.0000000000003312. Epub 2022 Oct 20. PubMed 36453656 ↗
  • Ihle-Hansen H, Vigen T, Berge T, Walle-Hansen MM, Hagberg G, Ihle-Hansen H, Thommessen B, Ariansen I, Rosjo H, Ronning OM, Tveit A, Lyngbakken M. Carotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort From the General Population. J Am Heart Assoc. 2023 Sep 5;12(17):e030739. doi: 10.1161/JAHA.123.030739. Epub 2023 Aug 23. PubMed 37609981 ↗

Related links

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 8, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01555411
Lead sponsor
Vestre Viken Hospital Trust
Collaborators
University Hospital, Akershus
Responsible party
Sponsor
First posted
Mar 15, 2012
Start date
Sep 2012
Primary completion
Dec 31, 2050 (estimated)
Completion
Dec 31, 2050 (estimated)
Last update
May 8, 2024

Study contacts

Arnljot Tveit, MD, PhD
study director · Vestre Viken Hospital Trust, Department of Medical Research
Helge Røsjø, MD, PhD
study director · University Hospital, Akershus
Trygve Berge - member of steering committee, MD
principal investigator · Vestre Viken Hospital Trust, Department of Medical Research
Kjetil Steine - member of steering committee, MD, PhD
principal investigator · University Hospital, Akershus
Torbjørn Omland - member of steering committee, MD, PhD
principal investigator · University Hospital, Akershus
Magnus N Lyngbakken - member of steering committee, MD
principal investigator · University Hospital, Akershus

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

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