An observational study in Spondylodiscitis, sponsored by Odense University Hospital. Suspended at 3 sites in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2013-02-18.
Sponsored by Odense University Hospital · Observational
MRI has shoved little correlation with the clinical finding during treatment of spondylodiscitis (infection in the vertebrae and/or discs). Since PET/CT is almost as good as MRI in diagnosing spondylodiscitis the hypothesis and this study is that PET/CT is better in predicting residual disease in patients with spondylodiscitis.
Preliminary study.
In the last years there has been reported increasing incidence of spondylodiscitis. The increase is mainly thought to be caused by the increasing elderly population and the increasing amount of spinal instrumentation in this population. The symptoms range from backache to severe neurological deficits. Up to 1/3 of cases are reported to be culture negative and cases can therefore be difficult to diagnose.
MRI is thought to be the main imaging technique to visualise infection. But with the increasing availability of 18-F FDG PET/CT, it is reported to be nearly as efficient to diagnose spinal infection.
During the long antibiotic treatment of spondylodiscitis, the clinicians have no real good imaging technique to predict residual disease since MRI during the remodelling fase of the spine will mimic no difference or worsening.
Since 18-F-FDG PET marks areas with a high amount of inflammatory cells it may also be faster in returning to normal images and therefore correlates better to actual status than MRI.
Some of the purposes of this study are therefore:
24 studies on the registry are indexed under Discitis; 5 are open to participants now.
This study's planned enrollment of 10 is below the median of 104 across 16 observational studies indexed under Discitis.
Browse Discitis studies →Odense University Hospital is the lead sponsor of 479 studies on the registry; 110 are open to participants now.
Counted across the registry records on this site, refreshed daily.
10 patients with MRI or PET/CT findings as well as overall clinical assessment compatible with spondylodiscitis.
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Exclusion Criteria:
The record gives a start of Mar 2012 and a completion of Mar 2013. It does not say whether these dates are actual or estimated.
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This study is suspended, as verified in Feb 2013. You cannot join it, but the record below documents what was studied.
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