An observational study in Infectious; Spondylitis, sponsored by Central Hospital, Nancy, France. Enrolling by invitation. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-08-08.
Sponsored by Central Hospital, Nancy, France · Observational
Infectious vertebral osteomyelitis are infectious diseases of the vertebral bone, intervertebral disc and/ or adjacent tissue. Most of cases are due to hematogenous dissemination of pathogen but direct inoculation is an aetiology after surgery. Majority of cases concern adults after 50 years and the annual incidence ranging between 0.5 and 2.4 cases per 100 000 habitants in Europe but seems to increase during last 20 years.
The infectious spondylodiscitis is an important source of morbidity and mortality. The treatment is based on pathogen adapted antimicrobial therapy, which may be associated with bedrest. Surgical act is necessary when neurological complication occurs or when vertebral column instability is too important. The immobilization in bed is use to limit pain and neurological complications. However, the immobilization is based on few literature data and causes important complications especially in elderly.
The of immobilization in Nancy universitity hospital changed in 2019 after institutional recommendations based on expert opinion which recommend an early verticalization of uncomplicated spondylodiscitis. The investigators aimed to evaluate the consequences of this practice change on the hospitalization duration and complication rates due to spondylodiscitis and immobilization.
626 studies on the registry are indexed under Communicable Diseases; 128 are open to participants now.
This study's planned enrollment of 200 is close to the median of 200 across 228 observational studies indexed under Communicable Diseases.
Browse Communicable Diseases studies →Central Hospital, Nancy, France is the lead sponsor of 798 studies on the registry; 186 are open to participants now.
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Patients with definite infectious spondylodiscitis hospitalised between 2016 and 2022 in Nancy University Hospital
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Exclusion Criteria:
Infectious spondylodiscitis when prolonged immoblization in bed was recommanded in our hospital
Infectious spondylodiscitis when early verticalization was recommanded in our hospital
Length of hospital stay
Duration between first and last day of hospitalisation in days
Time frame: when the patient is discharged from hospital (up to 52 weeks)
Rate of neurological complications
Measurement of the rate spondylodiscitis-related neurological complications in each group during hospitalisation
Time frame: During hospitalisation (up to 52 weeks)
Rate of immobilization complications
Measurement of the rate of bedrest complications in each group during hospitalisation
Time frame: During hospitalisation (up to 52 weeks)
Mortality
Patient death
Time frame: During hospitalisation (up to 52 weeks)
No study locations are listed for this record.
Ran from Jan 2016 to primary completion in Dec 2023, 95 months.
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Central Hospital, Nancy, France →