An interventional study of Biofreeze and Placebo in Musculoskeletal Disorders, sponsored by National Research Centre for the Working Environment, Denmark. Terminated at 1 site in Denmark. Open to participants aged 18 Years to 67 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-08-13.
Sponsored by National Research Centre for the Working Environment, Denmark · Not applicable, Interventional, and Treatment
Topical menthol gels are classified 'topical analgesics' and are used to relieve aching and tenderness of muscles and joints. However, double-blind randomized controlled trials are lacking. Here the investigators examine - in a double-blind randomized controlled cross-over trial - the acute effect of topical menthol (Biofreeze) and placebo (gel with a menthol scent) on neck pain.
657 studies on the registry are indexed under Musculoskeletal Diseases; 159 are open to participants now.
This study's planned enrollment of 20 is below the median of 73 across 438 interventional studies indexed under Musculoskeletal Diseases.
Browse Musculoskeletal Diseases studies →National Research Centre for the Working Environment, Denmark is the lead sponsor of 22 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
Topical gel containing a menthol scent, but no active menthol
Other: Placebo
Biofreeze topical gel containing 3.5% menthol
Other: Biofreeze
The gel will be applied at 2.5 ml per 500 cm2 to the upper trapezius and neck muscles by a gloved technician
Also known as: Topical analgesic
The gel will be applied at 2.5 ml per 500 cm2 to the upper trapezius and neck muscles by a gloved technician
Neck pain intensity (scale 0-10)
the participant rates pain intensity on a scale from 0-10 immediately before, and 0, 10, 20, 40 and 60 minutes after application of the gel. The primary efficacy endpoint is at 20 min
Time frame: before and 20 min after application
Pressure pain threshold (PPT)
pressure pain threshold of the upper trapezius muscle is measured by a handheld algometer immediately before, and 0, 10, 20, 40 and 60 minutes after application of the gel.
Time frame: before and 20 min after application
This study is terminated, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.
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National Research Centre for the Working Environment, Denmark