An observational study in Insulin Resistance, Cardiovascular Disease and Bone Loss, sponsored by University of Campinas, Brazil. Completed at 1 site in Brazil. Open to female participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-06-04.
Sponsored by University of Campinas, Brazil · Observational
Objective:
The purpose of this study is to determine the etiology of the weight increase in Depot-medroxyprogesterone Acetate (DMPA) users.
Method:
Prospective study with 100 women, aged 18-40 years old and BMI \< 30kg/m², paired with users of a non hormonal method follow for two years. Will be included only women who never used DMPA. There will be evaluated habit, blood pressure, anthropometric measure, distribution of corporal fat, lipids profile and glycemia parameters every six months. Thirty women and their control group will performed a euglycemic-hyperinsulinemic clamp to evaluate the resistance of insulin, adiponectin,neuropeptide Y, apolipoprotein A/B and arterial evaluation with ultrasound, intimal and media measure. Anova analysis for repeated samples. The metabolic alterations should elucidate the etiology, and the beginning of the sub clinical cardiovascular disease should be shown/discarded with the arterial evaluation.
4,905 studies on the registry are indexed under Cardiovascular Diseases; 919 are open to participants now.
This study's enrollment of 54 is below the median of 563 across 1,486 observational studies indexed under Cardiovascular Diseases.
Browse Cardiovascular Diseases studies →University of Campinas, Brazil is the lead sponsor of 166 studies on the registry; 13 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Will be included women new-users DMPA, looking for the clinic's family planning FCM-UNICAMP, from primary care centers in Campinas, São Paulo, Brazil.
Exclusion Criteria:
insulin resistance
insulin resistance diagnosed by hyperinsulinemic-euglycemic clamp at 0 and 12 months
Time frame: 12 months
weight gain
other arm of the study
Time frame: 12 months
eating disorder
other arm of the study
Time frame: 12 months
loss of bone mass
other arm of the study
Time frame: 12 months
changes in clotting factors
other arm of the study
Time frame: 12 months
This study is completed, as verified in Jun 2015. You cannot join it, but the record below documents what was studied.
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University of Campinas, Brazil