CompletedNCT01500954Updated Oct 16, 2012

Microarray Analysis of microRNA Expression Profiles in Cutaneous Squamous Cell Carcinoma

An observational study in Cutaneous Squamous Cell Carcinoma, sponsored by Ruhr University of Bochum. Completed at 1 site in Germany. Open to participants aged 1 Year and older. Per ClinicalTrials.gov, last updated 2012-10-16.

Sponsored by Ruhr University of Bochum · Observational

Study type: Observational
Model: Case-control
Time perspective: Prospective
Enrollment: 7
Ages: 1 Year and older
Sex: All

Study summary

MicroRNAs (miRNAs) are a novel class of short RNAs which have shown to be dysregulated in a variety of cancers. Data of miRNA expression in cutaneous squamous cell carcinoma (cSCC) is very limited and microarray based genome wide miRNA expression profiles of cSCC have not been investigated so far.

Read the detailed description

Patients with cutaneous SCC were enrolled in the present study. Tumor biopsies were taken from the center of the tumor. Adjacent healthy skin was biopsied as a control (intraindividual control). miRNA expression profiles of specimen were detected by microarray miRNA expression profiling. Microarray results were confirmed by TaqMan real-time quantitative polymerase chain reaction (RT-PCR).

Conditions studied

Cutaneous Squamous Cell Carcinoma

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In context

Carcinoma

6,738 studies on the registry are indexed under Carcinoma; 1,159 are open to participants now.

This study's enrollment of 7 is below the median of 149 across 1,175 observational studies indexed under Carcinoma.

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Lead sponsor

Ruhr University of Bochum is the lead sponsor of 124 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 1 Year and older
Sexes eligible: All
Accepts healthy volunteers: No
Sampling method: Non-probability sample

Study population

Patients with cutaneous squamous cell carcinoma

Inclusion criteria

cutaneous squamous cell carcinoma

Exclusion criteria

Exclusion Criteria:

other skin cancer than cutaneous squamous cell carcinoma

Study design

Observational model: Case-control
Time perspective: Prospective
Enrollment: 7 participants (actual)
Biospecimen retention: Samples with dna

Groups and cohorts

squamous cell carcinoma
non-lesional skin

Study locations

1 site

Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum
Bochum, NRW 44791, Germany

References and documents

Publications

Sand M, Skrygan M, Georgas D, Sand D, Hahn SA, Gambichler T, Altmeyer P, Bechara FG. Microarray analysis of microRNA expression in cutaneous squamous cell carcinoma. J Dermatol Sci. 2012 Dec;68(3):119-26. doi: 10.1016/j.jdermsci.2012.09.004. Epub 2012 Sep 13. PubMed 23026055 ↗

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Oct 16, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT01500954
Lead sponsor: Ruhr University of Bochum
Responsible party: Michael Sand (Principal Investigator, Ruhr University of Bochum) — Principal investigator
First posted: Dec 29, 2011
Start date: Oct 2011
Primary completion: Dec 2011
Completion: Dec 2011
Last update: Oct 16, 2012

Study contacts

Falk G Bechara, PD Dr.

study director · Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum

Peter Altmeyer, Prof. Dr.

study chair · Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum

Michael Sand, Dr.

principal investigator · Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum

Oversight

Data monitoring committee: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2012. You cannot join it, but the record below documents what was studied.

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