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CompletedNCT01430897Updated Sep 8, 2011

Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) Findings

An observational study in Right Ventricular Hypertrophy and d-TGA, sponsored by University of Leipzig. Completed at 1 site in Germany. Per ClinicalTrials.gov, last updated 2011-09-08.

Sponsored by University of Leipzig · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
37
Sex
All
01

Study summary

Systemic RV hypertrophy and impaired systolic function occur after atrial switch (AS) in d-transposition of the great arteries (d-TGA). Echocardiography has limitation in the assessment of the right ventricle (RV).

In this study the investigators sought to evaluate systemic RV myocardial mass and function after AS for d-TGA and to analyze the role of excessive hypertrophy for ventricular function under special consideration of the interventricular septal (IVS) movement.

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Conditions studied

  • Right Ventricular Hypertrophy
  • d-TGA

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Keywords

  • d-TGA
  • dextro Transposition of the great arteries
  • systemic right ventricle
  • right ventricular failure
  • Atrial switch procedure
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In context

Hypertrophy

656 studies on the registry are indexed under Hypertrophy; 87 are open to participants now.

This study's enrollment of 37 is below the median of 120 across 169 observational studies indexed under Hypertrophy.

Browse Hypertrophy studies →

Lead sponsor

University of Leipzig is the lead sponsor of 147 studies on the registry; 24 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Thirty-seven consecutive patients who came to regular outpatient visits at our tertiary care institution were referred to CMR.

Patient parameters were compared to a control group of 25 healthy age matched volunteers.

Inclusion criteria

  • Eligibility criteria were an AS operation in childhood for correction of d-TGA and the absence of associated hemodynamically significant heart defects.

Exclusion criteria

Exclusion Criteria:

  • Exclusion criteria were usual CMR contraindications such as ferromagnetic metallic implants.
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
37 participants (actual)
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Study locations

1 site
  • University of Leipzig - Heart Center
    Leipzig, 04289, Germany
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References and documents

Publications

  • Hornung TS, Kilner PJ, Davlouros PA, Grothues F, Li W, Gatzoulis MA. Excessive right ventricular hypertrophic response in adults with the mustard procedure for transposition of the great arteries. Am J Cardiol. 2002 Oct 1;90(7):800-3. doi: 10.1016/s0002-9149(02)02619-x. No abstract available. PubMed 12356407 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 8, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01430897
Lead sponsor
University of Leipzig
Responsible party
Matthias Grothoff, M.D. (Consultant Radiology, University of Leipzig) — Principal investigator
First posted
Sep 8, 2011
Start date
Apr 2007
Primary completion
Apr 2011
Completion
Sep 2011
Last update
Sep 8, 2011

Study contacts

Matthias Gutberlet, MD
study chair · University pf Leipzig - Heart Center

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2011. You cannot join it, but the record below documents what was studied.

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Other studies in this condition

Hypertrophy, Right Ventricular

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University of Leipzig

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