An interventional study of Strength physical training in Cardiac Remodeling, Ventricular and Right Ventricular Hypertrophy, sponsored by University Hospital, Caen. Completed at 1 site in France. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-02-13.
Sponsored by University Hospital, Caen · Not applicable, Interventional, and Basic science
Right ventricular (RV) physiological remodeling in response to prolonged strength exercise remains poorly studied. This prospective, non-randomized, single-center study, proposes to follow 24 healthy sedentary volunteers who will benefit from a high-intensity pure resistance training program over a 6-month period. The volunteers, aged between 18 and 40 years old and male, will be recruited and evaluated at the University Hospital center of Caen Normandy. Cardiac remodeling in response to physical exercise will be analyzed by trans-thoracic echocardiography repeated during the follow-up. The physical impact of the training program will be assessed by a treadmill exercise test predicting maximal oxygen consumption (VO2max) before and after completing the training, and an isokinetic muscular test repeated every 3 months. Participants rest/activity cycles will be monitor before and after 3 months of training. The aim of the study is to demonstrate the existence of a physiologic RV remodeling in response to pure high-load resistance chronic exercise. The results will help to improve the understanding of the physiological RV response expected in strength athletes.
105 studies on the registry are indexed under Ventricular Remodeling; 24 are open to participants now.
This study's enrollment of 27 is below the median of 81 across 72 interventional studies indexed under Ventricular Remodeling.
Browse Ventricular Remodeling studies →University Hospital, Caen is the lead sponsor of 512 studies on the registry; 82 are open to participants now.
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Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: Strength physical training
progressive high-load strength training over 6 months, consisting in repeated physical exercises to increase the muscular mass and force by altering concentric and eccentric muscle contractions against high resistance.
Assessment of right ventricular volumes change over 6 months of sustained high-strength physical training.
Analysis of variation in echocardiographic measurements of RV volumes before and after training
Time frame: Before the training starts and up to 6 months of follow-up
Plan to share: No
Ran from Jan 2022 to primary completion in Jun 2023, 17 months.
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This study is completed, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.
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