An observational study in Stillbirths and Sudden Infant Death, sponsored by Thayyil, Sudhin. Completed at 2 sites in United Kingdom. Open to participants aged Up to 18 Years. Per ClinicalTrials.gov, last updated 2013-04-22.
Sponsored by Thayyil, Sudhin · Observational
Among 16 studies in Stillbirth with a site in United Kingdom — 4 open to participants now, 4 under way, none of them phase 3. Stillbirth · United Kingdom.
Among the 16 studies in Stillbirth with a site in United Kingdom, this one is the 10th largest by planned enrollment of the 14 observational ones, is the only one that started in 2007, is one of 14 observational ones, and was the 2nd registered.
121 studies on the registry are indexed under Stillbirth; 34 are open to participants now.
This study's planned enrollment of 400 is below the median of 480 across 55 observational studies indexed under Stillbirth.
Browse Stillbirth studies →4 of the 16 studies in Stillbirth with a site in United Kingdom are open now, in 1 country. Each count lists the studies.
Of the 24 Stillbirth studies recruiting now, 10 (42%) set no upper age limit and 14 (58%) stop at 75 or younger; 10 take children under 18; 10 take healthy volunteers.
This study: Up to 18 Years · all sexes · no healthy volunteers.
The full table on the hub →16 studies; the count open now beside each. This study's row is marked.
First in 1995; this study’s year is marked. 1 started in 2007.
Median enrollment 217,136 across the 2 interventional studies, 989 across the 14 observational. Of the 10 that completed or were terminated, 1 (10%) have results posted.
None of the 16 has an industry lead sponsor. The 9 most frequent:
Thayyil, Sudhin is the lead sponsor of 6 studies on the registry; none are open to participants now.
Thayyil, Sudhin has 2 studies filed under Stillbirth — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 16 studies in Stillbirth with a site in United Kingdom, from their registry updates:
Nothing recorded among them since 2026-09-25.
The aim of this project is to establish whether magnetic resonance (MR) imaging can provide a minimally invasive approach for post-mortem assessment of the fetus, infant and child, with similar detection rates for anomalies and determination of the cause of death.
This will be achieved by acquiring a database of whole-body, post-mortem MR images in approximately 400 fetuses, infants and children, over a 3 years period. Images will be acquired on a dedicated 1.5T research MR scanner. MR images will be reported by an expert group of paediatric radiologists, and compared, in a blinded fashion, with reports from conventional autopsy performed by expert perinatal and paediatric pathologists. Importantly, the post-mortem information will be assessed with reference to the needs of the parents, referring clinicians and HM Coroners. The detection of central nervous system abnormalities will be assessed separately.
The study will be performed across two sites: A dedicated children's hospital (Great Ormond Street Hospital) and a teaching hospital, with large obstetric, fetal and neonatal departments (University College London Hospital), which are linked academically by University College London.
Co-ordination of the project will be managed by a steering committee, which will ensure accurate collation and comparison of the data.
This study will be performed across two hospital sites: Great Ormond Street Hospital for Children (GOSH) and University College London Hospitals (UCLH). Both of these hospitals are associated with a single academic institution - University College London (UCL). Consecutive fetuses, newborns and children referred for autopsy at these two hospitals will be eligible for recruitment. All recruited cases will have conventional post-mortem MR imaging at 1.5 Tesla and conventional autopsy. CT imaging will be performed in suspected traumatic injuries and skeletal dysplasias.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Still birth and Termination of pregnancies
Includes Newborns, Infants and Children
Number of cases where the cause of death and/or major pathological lesions are detected
Conventional autopsy will be considered as the gold standard. The number (%) of cases where post-mortem MR imaging identifies the cause of death and/or major pathological lesions when compared with conventional autopsy will be reported
Time frame: 6 weeks
MR appearance of death-induced artefacts.
The common artefacts seen on post-mortem MR imaging will be described
Time frame: 6 weeks
Number of cases where there is a change in ante-mortem diagnosis
Number of cases where there is a change in ante-mortem diagnosis following post-mortem MR imaging will be reported
Time frame: 6 weeks
The record gives a start of Mar 2007, a primary completion of Sep 2011 and a completion of Sep 2011. It does not say whether these dates are actual or estimated.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2013. You cannot join it, but the record below documents what was studied.
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Thayyil, Sudhin