ClinicalTrials.gg
CompletedNCT01120886Updated Apr 22, 2013

Post-mortem Genetic Testing

An observational study in Cardiac Ion Channelopathy, sponsored by Thayyil, Sudhin. Completed at 2 sites in United Kingdom. Open to participants aged 24 Weeks to 42 Weeks. Per ClinicalTrials.gov, last updated 2013-04-22.

Sponsored by Thayyil, Sudhin · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
100
Ages
24 Weeks to 42 Weeks
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 16 studies in Stillbirth with a site in United Kingdom — 4 open to participants now, 4 under way, none of them phase 3. Stillbirth · United Kingdom.

Planned enrollment
14th of 14
100 · median 989
Started
2011
the only one that year
Observational
14 of 16
4 open now
Registered
1st of 16
by date
Lead sponsor
2 of 16
Thayyil, Sudhin

Among the 16 studies in Stillbirth with a site in United Kingdom, this one is the 14th largest by planned enrollment of the 14 observational ones, is the only one that started in 2011, is one of 14 observational ones, and was the 1st registered.

By phase

16 studies; the count open now beside each. This study's row is marked.

Observationalthis study14 · 4 open
No phase2 · 0 open

By the year they started

First in 1995; this study’s year is marked. 1 started in 2011.

Size and results

Median enrollment 217,136 across the 2 interventional studies, 989 across the 14 observational. Of the 10 that completed or were terminated, 1 (10%) have results posted.

Was this useful?
Watch this landscapeDownload CSVWith an account: a weekly mail of what changed among 16 studies in Stillbirth with a site in United Kingdom, or all of them as a file.
02

Study summary

This is a prospective observational study to examine the incidence of cardiac ion channelopathies in unexplained still births.

03

Conditions studied

  • Cardiac Ion Channelopathy

Keywords

  • Ion channelopathy,
  • Still birth
  • Sudden death
04

Who can participate

Ages eligible
24 Weeks to 42 Weeks
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Unexplained still births

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Unexplained still births,
  • No cause of death after detailed autopsy

Exclusion criteria

Exclusion Criteria:

  • Lack of parental consent
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
100 participants (estimated)
Biospecimen retention
Samples with dna
06

What researchers measure

Primary outcomes

  1. Incidence of cardiac ion channelopathy mutation

    Time frame: 6 months

Secondary outcomes

  1. Incidence of cardiac ion channelopathy in 1st degree relatives of index case

    Time frame: 12 months

07

Study locations

2 sites
  • Great Ormond Street Hospital
    London, United Kingdom
  • Southampton University Hospital
    Southampton, United Kingdom
08

References and documents

Publications

  • Munroe PB, Addison S, Abrams DJ, Sebire NJ, Cartwright J, Donaldson I, Cohen MM, Mein C, Tinker A, Harmer SC, Aziz Q, Terry A, Struebig M, Warren HR, Vadgama B, Fowler DJ, Peebles D, Taylor AM, Lally PJ, Thayyil S. Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths. Circ Genom Precis Med. 2018 Jan;11(1):e001817. doi: 10.1161/CIRCGEN.117.001817. Epub 2018 Jan 11. PubMed 29874177 ↗
09

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Jan 2011, a primary completion of Mar 2013 and a completion of Mar 2013. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
May 7, 2010
First posted
May 11, 2010
Start
Jan 2011
Primary completionActual
Mar 2013
CompletionActual
Mar 2013
Last update
Apr 22, 2013
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 22, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01120886
Lead sponsor
Thayyil, Sudhin
Responsible party
Sudhin Thayyil (Consultant Neonatologist, Thayyil, Sudhin) — Principal investigator
First posted
May 11, 2010
Start date
Jan 2011
Primary completion
Mar 2013
Completion
Mar 2013
Last update
Apr 22, 2013

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2013. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion