An interventional study of artificially sweetened sodas in Obesity, Dyslipidemia and Metabolic Syndrome, sponsored by University of Lausanne. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2014-06-04.
Sponsored by University of Lausanne · Not applicable, Interventional, and Prevention
The study will enroll 68 overweight male and female subjects with a high (> 2 3dl-can soda/day) consumption of sweetened beverage per day. After a run-in period of 4 weeks, subjects will be randomized to either a 12-week intervention arm in which sweetened beverages will be replaced by artificially sweetened, calorie-free beverages, or to a control arm. The following measurements will be performed at the end of the run-in period and at the end of the intervention period
1,964 studies on the registry are indexed under Metabolic Syndrome; 330 are open to participants now.
This study's enrollment of 29 is below the median of 60 across 1,460 interventional studies indexed under Metabolic Syndrome.
Browse Metabolic Syndrome studies →University of Lausanne is the lead sponsor of 54 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
subjects will be required to consume only artificially-sweetened sodas, water, tea or coffee
Other: artificially sweetened sodas
subjects will continue their usual consumption of sweetened sodas
subjects will be allowed unlimited consumption of calorie-free, artificially-sweetened sodas, water, tea or coffee
changes in intrahepatic fat concentration
intrahepatic fat content measured by 1H-MRS
Time frame: at the end of run-in and after 12 weeks intervention/control
changes in visceral fat volume
Visceral fat volume measured by MRI
Time frame: at the end of run-in and after 12 weeks of intervention/control
changes in day-long metabolic profile
Plasma glucose, insulin, non-esterified fatty acids, and triglycerides will be measured at 2-hourly intervals between 7:00 am and 5:00 pm. Participants will be fed standardized meals and either sweetened or artificially-sweetened beverages according to randomization
Time frame: at the end of run-in and after 12 weeks of intervention/control
changes in food intake from baseline
Total energy intake, total carbohydrate intake, and total sugars intake will be evaluated by 3-day food record
Time frame: at the end of the run-in period and after 6, and 12 weeks of intervention/control
This study is completed, as verified in Jun 2014. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Lausanne