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CompletedNCT01315717GAITUpdated Sep 22, 2016

Gait and Alzheimer Interaction Tracking (GAIT) Study

An observational study in Gait Apraxia, Alzheimer Disease and Impaired Cognition, sponsored by University Hospital, Angers. Completed at 1 site in France. Open to participants aged 60 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-09-22.

Sponsored by University Hospital, Angers · Observational

Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
912
Ages
60 Years and older
Sex
All
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Study summary

The purpose of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and moderate dementia stages).

Read the detailed description

Although gait disorders are frequently associated with Alzheimer's disease (AD), few studies have focused on their characterization and mechanism. Exploring the associations of the gait characteristics - more particularly the gait variability - with the cognitive performance of AD patients on one hand, and with the morphological brain abnormalities on the other hand, could be useful to understanding the mechanisms of gait disorders in AD.

The main objective of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and moderate dementia stages).

02

Conditions studied

  • Gait Apraxia
  • Alzheimer Disease
  • Impaired Cognition
  • Cerebral Atrophy
03

In context

Alzheimer Disease

3,678 studies on the registry are indexed under Alzheimer Disease; 872 are open to participants now.

This study's enrollment of 912 is above the median of 200 across 751 observational studies indexed under Alzheimer Disease.

Browse Alzheimer Disease studies →

Lead sponsor

University Hospital, Angers is the lead sponsor of 464 studies on the registry; 116 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
60 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

All patients of the University Memory Center of Angers Hospital with respect to the eligibility criteria.

Inclusion criteria

  • Age ≥ 60 years
  • Able to walk without walking aid on 15 metres
  • Score of Mini-Mental Examination (MMSE) > 10
  • Written informed consent to participate in the study (or trustworthy person)
  • Being affiliated to a social security regime
  • Near visual acuity ≥ 2/10
  • Absence of severe depression (score in the 15-item Geriatric Depression Scale ≤ 10)

Exclusion criteria

Exclusion Criteria:

  • Score of Mini-Mental Examination (MMSE) ≤ 10
  • Subject suffering from pre-existing impellent disturbances
  • History of cerebrovascular accident or other cerebro-spinal pathology
  • Poor workmanship of the written or oral French language
  • Refusal of subject to be informed on possible hanging bare anomaly during study
  • Use of walking aid
  • Acute medical or surgical disease in the past 3 months
  • Refusal to participate (or trustworthy person)
  • Contra-indication to the achievement of a Magnetic Resonance Imaging
  • Near visual acuity \< 2/10
  • Presence of severe depression (score in the 15-item Geriatric Depression Scale > 10)
05

Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
912 participants (actual)

Groups and cohorts

  • Group 1

    Healthy subjects

  • Group 2

    Patients with Mild Cognitive Impairment

  • Group 3

    Patients with Mild AD

  • Group 4

    Patients with Moderate AD

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What researchers measure

Primary outcomes

  1. Stride-to-stride variability of stride time

    Time frame: baseline

07

Study locations

1 site
  • Angers University Hospital
    Angers, 49933, France
08

References and documents

Publications

  • Graffe A, Beauchet O, Fantino B, Milea D, Annweiler C. Vitamin D and macular thickness in the elderly: an optical coherence tomography study. Invest Ophthalmol Vis Sci. 2014 Jul 15;55(8):5298-303. doi: 10.1167/iovs.14-13918. PubMed 25028353 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 22, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01315717
Lead sponsor
University Hospital, Angers
Responsible party
Sponsor
First posted
Mar 15, 2011
Start date
Nov 2009
Primary completion
May 2016
Completion
May 2016
Last update
Sep 22, 2016

Study contacts

Olivier Beauchet, MD, PhD
principal investigator · Angers University Hospital

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2011. You cannot join it, but the record below documents what was studied.

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