An observational study in Epilepsies, sponsored by Institut National de la Santé Et de la Recherche Médicale, France. Completed at 1 site in France. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-01-23.
Sponsored by Institut National de la Santé Et de la Recherche Médicale, France · Observational
Surgery may be an effective therapy for refractory focal epilepsies with a clear delineated focus but surgical benefits are less clear for patients with a poorly defined focus such as non lesional refractory partial epilepsies.
SEEG is considered the criterion standard to localize the epileptogenic zone (EZ) but the procedure is risky with a limited spatial sampling. The development of non-invasive neuroimaging alternatives is thus an important goal to improve EZ delineation and optimize SEEG procedures.
The main hypothesis of this research project is the existence of a network organization specific for each patient which allows the generation and propagation of epileptic activities. The investigators wish to explore this network using diffusion tensor MRI to study structural connectivity and MEG/FMRI to study functional connectivity. The investigators will apply tools from the theories of complex networks and dynamical systems to characterize the network organization of epileptic process.
The investigators aimed to identify and localize differences in connectivity parameters between individual patients and a control group of healthy volunteers.
1,805 studies on the registry are indexed under Epilepsy; 417 are open to participants now.
This study's enrollment of 45 is below the median of 102 across 521 observational studies indexed under Epilepsy.
Browse Epilepsy studies →Institut National de la Santé Et de la Recherche Médicale, France is the lead sponsor of 375 studies on the registry; 82 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Refractory partial epilepsy patients
Exclusion Criteria:
Epilepsy patients selected before undergoing intracranial EEG recordings
Healthy volunteers
Epileptic network assessed using structural and functional connectivity measures obtained with MRI and MEG
Structural connectivity will be assessed using diffusion tensor MRI including the following parameters: mean diffusivity and anisotropy at voxel level, fiber tractography. Functional connectivity will be assessed using Rs-FMRI or MEG signal correlation measures. Cortical parcellation will allow the location of connectivity parameters calculated using the graph theory. Structural and functional data from one given patient will be statistically compared those of the control group.
Time frame: one year
This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.
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Institut National de la Santé Et de la Recherche Médicale, France