An interventional study of Intracranial macro-microelectrode recording in Focal Epilepsy, Electrodes, Implanted and Cognitive Function, sponsored by Institut National de la Santé Et de la Recherche Médicale, France. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-28.
Sponsored by Institut National de la Santé Et de la Recherche Médicale, France · Not applicable, Interventional, and Basic science
The main goal of this project is to study the mechanisms of epileptic activities using intracranial macro and micro electrodes in epileptic patients undergoing pre-surgical investigation.
The recordings will also be used to study physiological mechanisms like sleep and different cognitive functions.
Exclusion Criteria:
Implantation of macro-micro electrodes of the Adtech Benkhe-Fried type in epileptic patients who are undergoing evaluation with intracranial EEG electrodes
Device: Intracranial macro-microelectrode recording
Additionnally to clinical macroelectrodes, Benkhe-Fried depth macro-microelectrodes will be implanted and recorded during the pre-surgical investigation of epileptic patients
Identification of single unit changes at seizure emergence
In order to identify biomarkers of epileptic seizures we will study single neuron activities (firing rate) using spike sorting at different time periods (before, during and after seizures and during interictal periods) We expect to observe significant changes in firing rate across the different time periods.
Time frame: Whole duration of the clinical inverstigation, until 4 weeks
Identification of local field potential (LFP) changes at seizure emergence
In order to identify biomarkers of epileptic seizures we will study LFP power using time frequency analysis at different time periods (before, during and after seizures and during interictal periods) We expect to observe significant changes in LFP power across the different time periods.
Time frame: Whole duration of the clinical inverstigation, until 4 weeks
Comparison of single unit activity before seizure according to brain localization
We will compare firing rate before seizure according to brain regions (anatomy and involvement in the seizure onset zone)
Time frame: Whole duration ofthe clinical inverstigation, until 4 weeks
Identification of single unit changes during physiological brain activity
We will compare firing rates during resting states and stimulus induced states. We expect to observe significant changes in firing rate between states.
Time frame: Whole duration ofthe clinical inverstigation, until 4 weeks
Identification of LFP power changes during physiological brain activity
We will compare LFP power during resting states and stimulus induced states. We expect to observe significant changes in LFP power between states.
Time frame: Whole duration ofthe clinical inverstigation, until 4 weeks
Multilevel study of brain activity
We will look for correlation between firing rates and LFP power changes.
Time frame: Whole duration ofthe clinical inverstigation, until 4 weeks
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Institut National de la Santé Et de la Recherche Médicale, France