CClinicalTrials.gg
SuspendedNCT01305018Updated May 5, 2011

Branched-chain Amino Acids Supplementation and Resistance Exercise-induced Muscle Damage and Inflammation

An interventional study of BCAA and Leucine in Muscle Damage and Inflammation, sponsored by University of Sao Paulo. Suspended at 1 site in Brazil. Open to male participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-05-05.

Sponsored by University of Sao Paulo · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
18 Years to 30 Years
Sex
Male
01

Study summary

This study aims to evaluate the effects of branched-chain amino acids (BCAA) supplementation on resistance exercise-induced muscle damage and inflammation.

02

Conditions studied

  • Muscle Damage
  • Inflammation

Browse trials for

Keywords

  • Branched-chain amino acids
  • Leucine
  • Muscle damage
  • Inflammation
  • supplementation
  • resistance exercise-induced
03

In context

Inflammation

3,439 studies on the registry are indexed under Inflammation; 629 are open to participants now.

This study's planned enrollment of 30 is below the median of 50 across 2,437 interventional studies indexed under Inflammation.

Browse Inflammation studies →

Lead sponsor

University of Sao Paulo is the lead sponsor of 1,005 studies on the registry; 90 are open to participants now.

Of its 7 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 30 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Eligibility criteria

Inclusion Criteria:

  • Sedentary;
  • No muscle disorders;
  • Must be able to swallow tablets
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
30 participants (estimated)

Study arms

  • Experimental
    Exercise and BCAA

    Dietary Supplement: BCAA

  • Experimental
    Exercise and Leucine

    Dietary Supplement: Leucine

  • Placebo comparator
    Exercise and Placebo

    Dietary Supplement: Placebo

Interventions

  • Dietary supplementBCAA

    7 g of leucine + 3,5 g of isoleucine + 3,5 g of valine per day during 9 days

  • Dietary supplementLeucine

    7 g of leucine + 7 g of alanine per day during 9 days

  • Dietary supplementPlacebo

    14 g of alanine per day during 9 days

06

What researchers measure

Primary outcomes

  1. Muscle maximal strength

    Time frame: 4 days

  2. Muscle edema

    Time frame: 4 days

  3. Muscle soreness

    Time frame: 4 days

Secondary outcomes

  1. Muscle inflammation

    Immunohistochemistry, protein expression.

    Time frame: 4 days

  2. Muscle damage

    Serum creatine kinase

    Time frame: 4 days

07

Study locations

1 site
  • University of São Paulo - School of Physical Education and Sports
    São Paulo, 05508-030, Brazil
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 5, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01305018
Lead sponsor
University of Sao Paulo
First posted
Feb 28, 2011
Start date
Aug 2011
Primary completion
Jan 2012 (estimated)
Completion
Aug 2012 (estimated)
Last update
May 5, 2011

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is suspended, as verified in Apr 2011. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion