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Status unknownNCT01281826Updated Feb 11, 2011

Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures

An observational study in Compression Fracture of Thoracic Vertebral Body and Spinal Compression Fracture, sponsored by National Cheng-Kung University Hospital. Status unknown at 1 site in Taiwan. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2011-02-11.

Sponsored by National Cheng-Kung University Hospital · Observational

The sponsor has not verified this record recently (last verified Jan 2011), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
70
Ages
18 Years to 75 Years
Sex
All
01

Study summary

The purpose of this study is to

  1. Assess bone marrow edema within the VCF by use of a DE CT virtual noncalcium image compared with MR imaging as standard reference.
  2. Evaluate parameters related to the BME of the collapsed vertebral body on DE CT virtual noncalcium images, such as the morphologic signs, visual qualitative detection, and quantitative values.
Read the detailed description

Patients with multiple compression fractures and in those with chronic fracture, determining which vertebra to treat is frequently difficult. In such patients, the treatment location is commonly determined from findings at imaging, which includes magnetic resonance (MR) imaging, bone scintigraphy, and computed tomography (CT).

The bone marrow edema (BME) in acute/subacute VCFs is useful in determining the vertebra that is to be treated.

MR imaging provides information on anatomic vertebral collapse and the loss of normal T1 high signal intensity from the marrow space of vertebrae with acute fractures. Loss of normal T1 high signal intensity indicates the presence of BME, which is the important sign for the PVP treatment of VCFs.

Dual-energy (DE) CT has been used to create a virtual unenhanced scan by subtracting iodine from contrast agent-enhanced CT examinations.We expect that the same technique can be used to calculate a virtual noncalcium image from an unenhanced image, which makes bone marrow accessible for CT diagnosis.

02

Conditions studied

  • Compression Fracture of Thoracic Vertebral Body
  • Spinal Compression Fracture
03

In context

Fractures, Bone

2,261 studies on the registry are indexed under Fractures, Bone; 325 are open to participants now.

This study's planned enrollment of 70 is below the median of 100 across 675 observational studies indexed under Fractures, Bone.

Browse Fractures, Bone studies →

Lead sponsor

National Cheng-Kung University Hospital is the lead sponsor of 268 studies on the registry; 68 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients are recruited from Department of Orthopedics between january 2011 and december 2011.

Inclusion criteria

  • Compression fractures (thoracic and lumbar vertebrae)

Exclusion criteria

Exclusion Criteria:

  • Age less than 18 years
  • Pregnancy
  • Any contraindications to MR imaging.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
70 participants (estimated)
06

Study locations

1 of 1 sites recruiting
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 11, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT01281826
Lead sponsor
National Cheng-Kung University Hospital
First posted
Jan 24, 2011
Start date
Jan 2011
Primary completion
Dec 2011 (estimated)
Completion
Dec 2011 (estimated)
Last update
Feb 11, 2011

Study contacts

Chien-Kuo Wang
Contact
n044206@mail.hosp.ncku.edu.tw
886-6-2353535 ext. 2491
Chien-Kuo Wang
study chair · Department of Diagnostic Radiology Cheng Kung University Medicial Center

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2011. You cannot join it, but the record below documents what was studied.

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