An observational study in Breast Cancer, sponsored by National University Hospital, Singapore. Status unknown at 1 site in Singapore. Open to female participants. Per ClinicalTrials.gov, last updated 2014-01-22.
Sponsored by National University Hospital, Singapore · Observational
Adequate quality and quantity of RNA may be extracted from paraffin-embedded tumor blocks for gene expression analysis. This has clinical relevance as gene expression signatures may then be profiled using archival tumor blocks, which are more readily available than frozen tissues.
12,815 studies on the registry are indexed under Breast Neoplasms; 2,920 are open to participants now.
Browse Breast Neoplasms studies →National University Hospital, Singapore is the lead sponsor of 451 studies on the registry; 96 are open to participants now.
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Up to 10 archival breast tumor blocks will be obtained from the Department of Pathology, NUH - half of these blocks will be from patients who were diagnosed before year 2000, and the other half of the blocks will be from patients diagnosed between year 2000-2005 (control specimens). Basic tumor and patient information will be collected without patient identifiers - grade, stage, ER/PR/HER2 status, treatment received, outcome data. 8-10 ten-micron sections will be cut from each tumor block. RNA will be extracted from the tumor sections using the Roche High Pure FFPE RNA Micro Kit. RNA will be profiled using the Illumina Veracode assay and the Affymetrix Quantigene assay. RNA extraction and gene expression profiling will be performed by collabroators at the Genome Institute of Singapore.
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Breast Tumor Blocks
Other: Breast Tumor Blocks
This study is status unknown, as verified in Jan 2014. You cannot join it, but the record below documents what was studied.
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National University Hospital, Singapore →