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CompletedNCT01192425EXPLOREUpdated Jun 24, 2026

Paroxysmal Nocturnal Hemoglobinuria (PNH), Level of CD59 on Red and White Blood Cells in Bone Marrow Failure Syndromes

An observational study in Hemoglobinuria, sponsored by Alexion Pharmaceuticals, Inc.. Completed. Open to participants aged 10 Years and older. Per ClinicalTrials.gov, last updated 2026-06-24.

Sponsored by Alexion Pharmaceuticals, Inc. (part of AstraZeneca) · Observational

Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
5,580
Ages
10 Years and older
Sex
All
01

Study summary

Examine red and white blood cells of PNH patients with bone marrow failure syndromes.

02

Conditions studied

  • Hemoglobinuria

Keywords

  • PNH clone cells
  • Aplastic Anemia
  • AA
  • Myelodysplastic Syndromes
  • MDS
  • bone marrow failure syndromes
  • FLAER
  • Paroxysmal Nocturnal Hemoglobinuria
03

In context

Hemoglobinuria

14 studies on the registry are indexed under Hemoglobinuria; 2 are open to participants now.

Browse Hemoglobinuria studies →

Lead sponsor

Alexion Pharmaceuticals, Inc. is the lead sponsor of 255 studies on the registry; 23 are open to participants now.

Of its 101 completed or terminated interventional studies of FDA-regulated products, 75 (74%) have results posted.

First submitted before Alexion Pharmaceuticals, Inc. became part of AstraZeneca.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
10 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients at least 10 years of age with aplastic anemia, myelodyplastic syndromes or other bone marrow failure syndromes.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • At least 10 years of age.
  • Has aplastic anemia, myelodysplastic syndromes or other bone marrow failure syndromes

Exclusion criteria

Exclusion Criteria:

  • Has any condition that might interfere with the patient's participation
05

Study design

Observational model
Other
Time perspective
Prospective
Enrollment
5,580 participants (actual)
06

Study locations

No study locations are listed for this record.

07

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Sep 2010 to primary completion in Sep 2010, 0 months.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 30, 2010
First posted
Sep 1, 2010
StartActual
Sep 1, 2010
Primary completionActual
Sep 2010
CompletionActual
Sep 2010
Last update
Jun 24, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jun 24, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT01192425
Responsible party
Sponsor
First posted
Sep 1, 2010
Start date
Sep 1, 2010
Primary completion
Sep 2010
Completion
Sep 2010
Last update
Jun 24, 2026

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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