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CompletedNCT01175629Updated Jul 2, 2014

Veteran Health Study

An observational study in Stress Disorders, Post-Traumatic, Depression and Diabetes, sponsored by US Department of Veterans Affairs. Completed at 1 site in United States. Open to male participants. Per ClinicalTrials.gov, last updated 2014-07-02.

Sponsored by US Department of Veterans Affairs · Observational

Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
7,568
Sex
Male
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Study summary

The purpose of The Veteran Health Study (CSP #569) is to better understand the mental and physical health of veterans as they get older. We are inviting approximately 10,000 members of the Vietnam Era Twin (VET) Registry to participate. As veterans approach their mid-sixties, it is important to understand the impact of wartime deployment on health and mental health outcomes nearly 40 years later.

The investigators will assess the prevalence of post-traumatic stress disorder (PTSD) and other mental and physical health conditions for Vietnam era veterans, and explore the relationship between PTSD and other conditions.

CSP #569 involves 3 phases of data collection. In Phase I, VET Registry members are invited to complete a paper and pencil questionnaire including items on physical and mental health, disability, health behaviors, demographic information and use of health care services. After completing Phase I, VET Registry members are invited to Phase II which involves a telephone interview about mental health. In Phase III, some of those who participated in Phase I will be invited to a sub-study confirming self-reported heart disease and diabetes using a provider survey.

Data collected for CSP #569 will be combined with existing VET Registry data. This will provide a rich picture of the health of Vietnam era veterans and the influence of PTSD on the lives of veterans.

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Conditions studied

  • Stress Disorders, Post-Traumatic
  • Depression
  • Diabetes
  • Cardiovascular Disease

Keywords

  • Stress Disorders, Post-Traumatic
  • Depression
  • Diabetes
  • Cardiovascular Disease
  • Depressive Disorder
  • Behavioral Symptoms
  • Metabolic Diseases
  • Mental Disorders
  • Anxiety Disorders
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In context

Cardiovascular Diseases

4,904 studies on the registry are indexed under Cardiovascular Diseases; 919 are open to participants now.

This study's enrollment of 7,568 is above the median of 573 across 1,485 observational studies indexed under Cardiovascular Diseases.

Browse Cardiovascular Diseases studies →

Lead sponsor

US Department of Veterans Affairs is the lead sponsor of 658 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
Male
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All subjects are members of the Vietnam Era Twin Registry, and are males born between 1939-1957.

Inclusion criteria

  • All twins who are currently active in the VET Registry will be invited to participate in CSP #569.

Exclusion criteria

Exclusion Criteria:

  • Unable or unwilling to provide informed consent
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Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
7,568 participants (actual)

Groups and cohorts

  • Group 1

    The Vietnam Era Twin (VET) Registry is a closed cohort composed of 7,369 middle-aged male-male twin pairs both of whom served in the military during the time of the Vietnam conflict (1965-1975). The Registry is a United States Department of Veterans Affairs resource that was originally constructed from military records; the Registry has been in existence for more than 15 years. It is one of the largest national twin registries in the US and currently has subjects living in all 50 states. Initially formed to address questions about the long-term health effects of service in Vietnam the Registry has evolved into a resource for genetic epidemiological studies of mental and physical health conditions. Several waves of mail and telephone surveys have collected a wealth of health-related information on Registry twins. Other data collection efforts have focused on specific sets of twin pairs and conducted detailed clinical or laboratory testing.

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What researchers measure

Primary outcomes

  1. Determine the prevalence of lifetime and current psychiatric conditions including PTSD in Vietnam Era Twin Registry members who served during the Vietnam Era.

    Time frame: two years

Secondary outcomes

  1. Characterize the physical health of Vietnam Era Twin Registry members who served during the Vietnam Era.

    Time frame: two years

  2. Characterize the level of current disability in Vietnam Era Twin Registry members who served during the Vietnam Era.

    Time frame: two years

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Study locations

1 site
  • VA Puget Sound Health Care System
    Seattle, Washington 98101, United States
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References and documents

Publications

  • Magruder K, Yeager D, Goldberg J, Forsberg C, Litz B, Vaccarino V, Friedman M, Gleason T, Huang G, Smith N. Diagnostic performance of the PTSD checklist and the Vietnam Era Twin Registry PTSD scale. Epidemiol Psychiatr Sci. 2015 Oct;24(5):415-22. doi: 10.1017/S2045796014000365. Epub 2014 Jun 6. PubMed 24905737 ↗
  • Vaccarino V, Goldberg J, Magruder KM, Forsberg CW, Friedman MJ, Litz BT, Heagerty PJ, Huang GD, Gleason TC, Smith NL. Posttraumatic stress disorder and incidence of type-2 diabetes: a prospective twin study. J Psychiatr Res. 2014 Sep;56:158-64. doi: 10.1016/j.jpsychires.2014.05.019. Epub 2014 Jun 9. PubMed 24950602 ↗
  • Goldberg J, Magruder KM, Forsberg CW, Kazis LE, Ustun TB, Friedman MJ, Litz BT, Vaccarino V, Heagerty PJ, Gleason TC, Huang GD, Smith NL. The association of PTSD with physical and mental health functioning and disability (VA Cooperative Study #569: the course and consequences of posttraumatic stress disorder in Vietnam-era veteran twins). Qual Life Res. 2014 Jun;23(5):1579-91. doi: 10.1007/s11136-013-0585-4. Epub 2013 Dec 7. PubMed 24318083 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 2, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01175629
Lead sponsor
US Department of Veterans Affairs
Responsible party
Sponsor
First posted
Aug 5, 2010
Start date
Jan 2010
Primary completion
Sep 2012
Completion
Mar 2013
Last update
Jul 2, 2014

Study contacts

Jack H Goldberg, PhD MA BA
study chair · VA Puget Sound Health Care System, Seattle
Kathryn M. Magruder, PhD MPH BA
study chair · Ralph H Johnson VA Medical Center, Charleston

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2014. You cannot join it, but the record below documents what was studied.

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