An Early Phase 1 interventional study of Transplantation of Bone Marrow Stem Cells Activated in Knee Arthrosis in Osteoarthritis, Knee Osteoarthritis and Osteochondritis Dissecans, sponsored by Michel Assor, MD. Status unknown at 1 site in France. Open to participants aged 30 Years to 75 Years. Per ClinicalTrials.gov, last updated 2013-01-08.
Sponsored by Michel Assor, MD · Early Phase 1, Interventional, and Treatment
Among 124 studies in Osteoarthritis, Knee with a site in France — 23 open to participants now, 33 under way, 1 of them phase 3. Osteoarthritis, Knee · France.
Among the 124 studies in Osteoarthritis, Knee with a site in France, this one is the 62nd largest by planned enrollment of the 86 interventional ones that give a count, is one of 4 that started in 2010, is one of 5 in phase 1, and was the 17th registered.
3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.
Browse Osteoarthritis, Knee studies →23 of the 124 studies in Osteoarthritis, Knee with a site in France are open now. Recruiting first, the newest first:
GCS Ramsay Santé pour l'Enseignement et la Recherche · Sites in France
Ages 18+
University Hospital, Brest · Sites in France
Ages 18–90
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer · Sites in France
Ages 18+
Assistance Publique - Hôpitaux de Paris · Sites in France
Ages 40–79
Assistance Publique - Hôpitaux de Paris · Sites in France
Ages 18–70
A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →
Of the 382 Osteoarthritis, Knee studies recruiting now, 176 (46%) set no upper age limit and 113 (30%) stop at 75 or younger; 19 take children under 18; 39 take healthy volunteers.
This study: 30 Years to 75 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
124 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 6 · Phase 2 10 · Phase 3 10 · Phase 4 6
First in 1999; this study’s year is marked. 4 started in 2010.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 50 is below the median of 68 across 2,714 interventional studies indexed under Osteoarthritis, Knee.
Median enrollment 106 across the 86 interventional studies, 100 across the 34 observational. Of the 73 that completed or were terminated, 7 (10%) have results posted.
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38 of 124 have an industry lead sponsor. The 10 most frequent:
This is the only study on the registry with Michel Assor, MD as lead sponsor.
Michel Assor, MD has 1 study filed under Osteoarthritis, Knee — fewer than ten, so there is no comparison to draw.
8 of the studies in Osteoarthritis, Knee with a site in France that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT03522025Medacta International SAGMK-UNI Anatomical UKA: Fixation of Cemented vs Cementless Designs | 2026-12-01 |
| NCT06617975CEN BiotechKnee Osteoarthritis and Spa Therapy | 2026-12-15 |
| NCT07370480CEN BiotechKnee Osteoarthritis and Thermal Spa Treatment | 2027-02-10 |
| NCT05488093University Hospital, MontpellierEvaluation of Mobility in Subjects With Severe Knee Osteoarthritis Who Are to Undergo Total Knee Replacement | 2027-03 |
| NCT06676189University Hospital, Clermont-FerrandComparison of Pivotal Medial Polyethylene Versus Ultra-congruent in Total Knee Arthroplasty | 2027-03 |
Add all 8 to your calendar (.ics) → With an account.
Among the 124 studies in Osteoarthritis, Knee with a site in France, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The purpose of this pilot study is to investigate the efficacy and safety of autologous transplantation, under arthroscopy, of Bone Marrow Mesenchymal stem cells, using, with a cell separator, a fresh non-culture expanded Autologous Bone Marrow derived Mesenchymal Stem, mixed and activated with proteins scaffold in patient with Knee cartilage defects and osteoarthritis. Based on extensive preclinical investigations, the technology of using freshly isolated bone marrow mononuclear cells mixed with proteins seems safe and most effective for a one-step correction of cartilage defect and restoration of the osteochondral complex, because the same mixture can generate cartilage in the vasculature-free knee joint, and bone in the environment of bone defects.
Before the implantation of the mesenchymal stem cells, a knee arthroscopy procedure is made for the debridement of the meniscal and cartilage lesions, with microperforation and abrasion, preparation of the osteochondral defect to receive the transplantation, patellar lateral release if necessary.
Then, the investigators use a fresh non-culture expanded autologous bone marrow derived mesenchymal mononuclear stem cells, stimulated with a protein matrix and mixed in a collagen hydroxyapatite scaffold. This cellular paste is transplanted in the prepared defect, under arthroscopy, with injection of platelet rich plasma.
3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.
This study's planned enrollment of 50 is below the median of 68 across 2,714 interventional studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →This is the only study on the registry with Michel Assor, MD as lead sponsor.
Compared within Osteoarthritis, Knee, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Osteoarthritis. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Transplantation of Activated Bone Marrow Stem Cells in Knee Arthrosis, under arthroscopy, in one-step procedure
Also known as: mesenchymal stem cells, Knee Arthrosis, Knee osteochondral defect
IKS, International Knee Score
measure assess of the knee function
Time frame: 6 months
IKS, International Knee Score
measure assess of the knee function
Time frame: 1 year
KOOS, Knee Injury and Osteoarthritis Outcome Score
measure assess of the knee function and quality of the new cartilage
Time frame: 6 months
KOOS, Knee Injury and Osteoarthritis Outcome Score
measure assess of the knee function and quality of the new cartilage
Time frame: 1 year
The record gives a start of Jul 2010, a primary completion of Dec 2014 and a completion of Dec 2014. It does not say whether these dates are actual or estimated.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Jan 2013. You cannot join it, but the record below documents what was studied.
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