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WithdrawnNCT01151748Updated May 14, 2012

Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma

A Phase 2 interventional study of Intra-arterial infusion of chemotherapy in Retinoblastoma and Eye Cancer, sponsored by Stanford University. Withdrawn at 1 site in United States. Open to participants aged Up to 18 Years. Per ClinicalTrials.gov, last updated 2012-05-14.

Sponsored by Stanford University · Phase 2, Interventional, and Treatment

Why this study was withdrawn
Study abandoned; Could not obtain final SRC approval due to IND disagreements
Phase
Phase 2
Study type
Interventional
Enrollment
0
Allocation
Non-randomized
Ages
Up to 18 Years
Sex
All
01

Study summary

Phase II study of selective intra-arterial infusion of chemotherapy for intraocular retinoblastoma

02

Conditions studied

  • Retinoblastoma
  • Eye Cancer
03

In context

Retinoblastoma

124 studies on the registry are indexed under Retinoblastoma; 23 are open to participants now.

Browse Retinoblastoma studies →

Lead sponsor

Stanford University is the lead sponsor of 2,117 studies on the registry; 425 are open to participants now.

Of its 259 completed or terminated interventional studies of FDA-regulated products, 197 (76%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Up to 18 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  1. Patients diagnosed with advanced intraocular retinoblastoma (International Retinoblastoma Classification group D or E*).
  2. Patients with tumor recurrence or vitreous seeding following completion of systemic chemotherapy or previous radiation therapy.

Exclusion criteria

Exclusion Criteria:

  1. Congenital brain anomaly identified on MRI.
  2. History of systemic coagulopathy.
  3. Evidence of extra ocular retinoblastoma on clinical examination or neuroimaging.
05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
0 participants (actual)

Interventions

  • ProcedureIntra-arterial infusion of chemotherapy
06

What researchers measure

Primary outcomes

  1. Response: Globe salvage rate (Eyes saved/Eyes treated). This will be determined by clinical ocular examination.

    Time frame: Follow-up will be performed for one year from treatment date.

07

Study locations

1 site
  • Stanford University School of Medicine
    Stanford, California 94305, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 14, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01151748
Lead sponsor
Stanford University
Responsible party
Sponsor
First posted
Jun 28, 2010
Start date
Sep 2010
Primary completion
Mar 2011 (estimated)
Completion
Mar 2012 (estimated)
Last update
May 14, 2012

Study contacts

Jonathan W Kim
principal investigator · Stanford University
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in May 2012. You cannot join it, but the record below documents what was studied.

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