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CompletedNCT01139333Updated May 18, 2016

Blood and Tumor Tissue Samples From Young Patients With Acute Myeloid Leukemia

An observational study in Leukemia, sponsored by Children's Oncology Group. Completed. Open to participants aged Up to 17 Years. Per ClinicalTrials.gov, last updated 2016-05-18.

Sponsored by Children's Oncology Group · Observational

Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
52
Ages
Up to 17 Years
Sex
All
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Study summary

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is studying blood and tumor tissue samples from young patients with acute myeloid leukemia.

Read the detailed description

OBJECTIVES:

  • To evaluate Mer and Axl expression in samples from pediatric patients with acute myeloid leukemia (AML).
  • To determine if abnormal expression of Mer and Axl is associated with poor clinical characteristics (e.g., induction failure or relapse) of AML in these patients.

OUTLINE: This is a multicenter study.

Archived samples from pediatric patients with acute myeloid leukemia are analyzed for Mer and Axl expression by flow cytometry and western blot assays.

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Conditions studied

  • Leukemia

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Keywords

  • childhood acute myeloid leukemia/other myeloid malignancies
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In context

Leukemia

5,475 studies on the registry are indexed under Leukemia; 629 are open to participants now.

This study's planned enrollment of 52 is below the median of 120 across 747 observational studies indexed under Leukemia.

Browse Leukemia studies →

Lead sponsor

Children's Oncology Group is the lead sponsor of 447 studies on the registry; 35 are open to participants now.

Of its 12 completed or terminated interventional studies of FDA-regulated products, 11 (92%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Up to 17 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Diagnosis of acute myeloid leukemia

Eligibility criteria

DISEASE CHARACTERISTICS:

  • Diagnosis of acute myeloid leukemia
  • Children Oncology Group (COG) patient samples

PATIENT CHARACTERISTICS:

  • Available clinical data

PRIOR CONCURRENT THERAPY:

  • Not specified
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Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
52 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Interventions

  • Geneticgene expression analysis
  • Geneticwestern blotting
  • Otherflow cytometry
  • Otherlaboratory biomarker analysis
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What researchers measure

Primary outcomes

  1. Expression of Mer and Axl

  2. Association of abnormal expression of Mer and Axl with induction failure or relapse

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Study locations

No study locations are listed for this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 18, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01139333
Responsible party
Sponsor
First posted
Jun 8, 2010
Start date
Sep 2009
Primary completion
May 2016
Last update
May 18, 2016

Study contacts

Kristen M. Eisenman, MD
principal investigator · University of Colorado, Denver

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2016. You cannot join it, but the record below documents what was studied.

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