A Phase 4 interventional study of Computerized Cognitive Skill Training and CRT and Social Cognition in Schizophrenia and Schizoaffective Disorder, sponsored by Nathan Kline Institute for Psychiatric Research. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-07-21.
Sponsored by Nathan Kline Institute for Psychiatric Research · Phase 4, Interventional, and Treatment
The study is designed to evaluate the effectiveness of computerized cognitive skills training for improving memory and problem-solving skills in inpatients with schizophrenia.
Subjects are stable inpatients and outpatients with schizophrenia or schizoaffective disorder who are receiving atipsychotic medication at Manhattan Psychiatric Center.
Patients receive baseline assessments (MCCB-MATRICS; Personal and Social Performance Scale, FEDT/FEIT and PANSS) and then are assigned to Cognitive Remediation (CRT) using the COGPACK program, patients are then randomly assigned to a social cognition program (Mind Reader Interactive Guide to Emotions) for a period of 12 weeks. Following 12 weeks of treatment in either CRT + Mind Reader or CRT alone, assessments are repeated by raters.
Cognitive Remediation (CRT): CRT (COGPACK, Marker and Olbrich, 1998) consists of computerized practice tests for seven cognitive domains. There are 64 programs for testing and training, each with several variants for the domains of visuomotor skills, comprehension, reaction, vigilance, memory, language, and intellectual skills. Exercises in COGPACK can be edited and expanded. Patients attend 2 (45-minutes each) groups and 1 discussion group.
Social Cognition Training: Mind Reader (Baron-Cohen et al, 2004) is an interactive computerized program of emotions and mental states. It is based on a taxonomic system of 412 emotions and mental states, grouped into 24 emotion groups, and six developmental levels (from age 4 to adulthood). The emotions and mental states are organized systematically, according to the emotion groups and developmental levels. Patients assigned to Mind Reader attend 1 group per week.
Both the CRT and Mind Reader are administered in small groups of six to eight patients each.
3,470 studies on the registry are indexed under Schizophrenia; 471 are open to participants now.
This study's enrollment of 448 is above the median of 70 across 2,871 interventional studies indexed under Schizophrenia.
Browse Schizophrenia studies →Nathan Kline Institute for Psychiatric Research is the lead sponsor of 22 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Two arms: 1. Computerized Cognitive Remediation treatment using COGPACK. and 2. PositScience. Each arm is further randomized to either MindReader or no Mindreader.(Social Cognition Training).
Behavioral: Computerized Cognitive Skill Training
Two 45-minute sessions of Computerized Cognitive Remediation using COGPACK, one 45-minute discussion session, plus one 45 minute Mind Reader Interactive Guide to Emotions per week for 12 weeks. compared to two 45-minute sessions of PositScience, plus one 45-min Discussion session plus one minute of Mind Reader, Interactive Guide to Emotions
Behavioral: CRT and Social Cognition
Behavioral: Cognitive Remediation 45 mins 2 times per week sessions of cognitive remediation (COGPACK) over twelve weeks.
Also known as: Cognitive Remediation Therapy
Mind Reading, The Interactive Guide to Emotions for one 45 minute session per week for 12 weeks.
Also known as: Social Emotional Functioning
Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS)
Comprehensive battery of neuro-cognitive tests
Time frame: Week 0, and Week 12 (after completion of Cognitive Remediation)
Facial Emotional Discrimination Task (FEDT) and Facial Emotional Identification Task (FEIT)
Test of facial emotion presentations on pictures to patients
Time frame: Week 0, and Week 12 (after compeltion of Cognitive Remediation)
Personal and Social Performance Scale (PSP)
Social function scale with four sub domains of social functioning
Time frame: Week 0, and Week 12 after completion of Cognitive Remediation
Positive and Negative Syndrome Scale (PANSS)
30 item Gold standard for measurement of psychiatric symptoms
Time frame: Week 0, Week 6 (Midpoint) and Week 12 after completion of Cognitive Remediation
This study is completed, as verified in Jul 2017. You cannot join it, but the record below documents what was studied.
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Nathan Kline Institute for Psychiatric Research