CompletedNCT01019538Updated Jul 6, 2011

Pre-flight Titration of Supplemental Oxygen

An observational study in Chronic Obstructive Pulmonary Disease, sponsored by Ullevaal University Hospital. Completed at 1 site in Norway. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2011-07-06.

Sponsored by Ullevaal University Hospital · Observational

Study type: Observational
Model: Case-only
Time perspective: Prospective
Enrollment: 20
Ages: 18 Years and older
Sex: All

Study summary

The purpose of this study is to evaluate if supplemental oxygen during air travel can be reliably titrated using a Hypoxia-altitude simulation test (HAST). Also, the effect of oxygen supplementation given with the various oxygen equipment allowed for air travel is studied.

Read the detailed description

International guidelines recommend supplemental oxygen if PaO2 \< 6.7 kPa (50 mmHg) during air travel. Hypobaric chamber exposure is the ideal test but is not widely available. In clinical practice, the HAST has been recommended as the preferable test for pre-flight evaluation, and is used with increasing frequency. The oxygen dose during air travel has been recommended titrated during HAST. In the study, supplemental oxygen titration during hypobaric chamber exposure is compared to oxygen titration during HAST, to evaluate if HAST can be used with confidence to titrate the amount of supplemental oxygen needed during air travel.

Conditions studied

Chronic Obstructive Pulmonary Disease

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Keywords

Oxygen
Hypoxemia
Air travel

In context

Lung Diseases, Obstructive

2,592 studies on the registry are indexed under Lung Diseases, Obstructive; 198 are open to participants now.

This study's planned enrollment of 20 is below the median of 150 across 639 observational studies indexed under Lung Diseases, Obstructive.

Browse Lung Diseases, Obstructive studies →

Lead sponsor

Ullevaal University Hospital is the lead sponsor of 76 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years and older
Sexes eligible: All
Accepts healthy volunteers: No
Sampling method: Probability sample

Study population

COPD patients

Inclusion criteria

COPD patients who have performed a Hypoxia-altitude simulation test with a PaO2 \< 6.7 kPa

Exclusion criteria

Exclusion Criteria:

exacerbation or pneumothorax within the previous six weeks
LTOT
anemia
pulmonary disease other than COPD
cerebrovascular or symptomatic cardiovascular disease
claustrophobia
inability to equalize pressure in the middle ear

Study design

Observational model: Case-only
Time perspective: Prospective
Enrollment: 20 participants (estimated)
Biospecimen retention: Samples without dna

Interventions

OtherPre-flight test with supplemental oxygen
The Hypoxia-altitude simulation test, which is established in clinical practice, is compared to the gold standard of hypobaric chamber while giving supplemental gaseous oxygen without and with oxygen conserving device, and with oxygen concentrator.
Also known as: Oxygen

What researchers measure

Primary outcomes

PaO2 obtained from oxygen titration during HAST vs hypobaric chamber
Time frame: 1 day

Study locations

1 site

Oslo University Hospital Ullevaal, Department of Pulmonary Medicine
Oslo, 0407, Norway

References and documents

Publications

Gong H Jr, Tashkin DP, Lee EY, Simmons MS. Hypoxia-altitude simulation test. Evaluation of patients with chronic airway obstruction. Am Rev Respir Dis. 1984 Dec;130(6):980-6. doi: 10.1164/arrd.1984.130.6.980. PubMed 6508019 ↗
Akero A, Christensen CC, Edvardsen A, Skjonsberg OH. Hypoxaemia in chronic obstructive pulmonary disease patients during a commercial flight. Eur Respir J. 2005 Apr;25(4):725-30. doi: 10.1183/09031936.05.00093104. PubMed 15802350 ↗
Akero A, Christensen CC, Edvardsen A, Ryg M, Skjonsberg OH. Pulse oximetry in the preflight evaluation of patients with chronic obstructive pulmonary disease. Aviat Space Environ Med. 2008 May;79(5):518-24. doi: 10.3357/asem.2120.2008. PubMed 18500050 ↗
Dine CJ, Kreider ME. Hypoxia altitude simulation test. Chest. 2008 Apr;133(4):1002-5. doi: 10.1378/chest.07-1354. PubMed 18398121 ↗
Akero A, Edvardsen A, Christensen CC, Owe JO, Ryg M, Skjonsberg OH. COPD and air travel: oxygen equipment and preflight titration of supplemental oxygen. Chest. 2011 Jul;140(1):84-90. doi: 10.1378/chest.10-0965. Epub 2010 Nov 11. PubMed 21071527 ↗

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Jul 6, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT01019538
Lead sponsor: Ullevaal University Hospital
First posted: Nov 25, 2009
Start date: Dec 2008
Primary completion: Apr 2010
Completion: Apr 2010
Last update: Jul 6, 2011

Study contacts

Ole H Skjønsberg, Prof.dr.med

study director · Oslo University Hospital

Aina Akerø, M.D.

principal investigator · Oslo University Hospital

Oversight

Data monitoring committee: Yes

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2009. You cannot join it, but the record below documents what was studied.

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Discussion

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