An interventional study of Oat bran and Spray-dried oat drink in Hypoglycemia and Hyperglycemia, sponsored by Lund University. Completed at 1 site in Sweden. Open to participants aged 20 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-10-30.
Sponsored by Lund University · Not applicable and Interventional
The aim of this study is to
Dietary fiber has long been known to give beneficial health effects. Yet, the understanding of how fiber-rich meals regulate molecular events at a gene level is limited. Also, few studies have compared the effects of different fiber sources on postprandial responses and hardly any study the effects of fiber mixtures in the same meal, even though this is more similar to regular eating habits.
Healthy subjects will come to the study center after an overnight fast, to ingest breakfasts randomly enriched with different fiber. The meals contains either spray-dried oat drink, rye bran, sugar beet fiber a mixture of these three fibers, oat bran or no added fiber (control). All meals are adjusted to contain the same total amount of available carbohydrates and fat. Blood leukocytes for gene expression profiling were taken before and 2 h after consumption while blood samples for analysis of postprandial glucose, insulin and triglyceride levels were taken every 30 min during 3 h.
NuGO Affymetrix Human Genechip NuGO_Hs1a520180 are used for the microarray analysis and analysis is performed with linear mixed models and enrichment analysis to identify functional gene sets that responded to the specific oat bran effect.
640 studies on the registry are indexed under Hypoglycemia; 86 are open to participants now.
This study's enrollment of 18 is below the median of 29 across 471 interventional studies indexed under Hypoglycemia.
Browse Hypoglycemia studies →Lund University is the lead sponsor of 230 studies on the registry; 37 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Single intake of a mixture of spray-dried oat drink, rye bran and sugar beet fiber
Other: Mixture of fiber
Single intake of sugar beet fiber
Other: Sugar beet fiber
Single intake of rye bran
Other: Rye bran
Single intake of oat bran
Other: Oat bran
Single intake of spray-dried oat drink
Other: Spray-dried oat drink
Single intake of a meal with no added fiber
Other: Control
82 g oat bran was added to 250 ml blackcurrant beverage with pulp to give 5 g soluble fiber (12.6 g total fiber).
Also known as: Oats, Beta-glucan
62 g spray-dried oat drink was added to 250 ml blackcurrant beverage with pulp to give 2.7 g soluble fiber (3.3 g total fiber).
Also known as: Oats, Oat milk, Beta-glucan
31 g rye bran was added to 250 ml blackcurrant beverage with pulp to give 1.7 g soluble fiber (12 g total fiber).
Also known as: Rye, Arabinoxylan
19 g sugar beet fiber was added to 250 ml blackcurrant beverage with pulp to give 5 g soluble fiber (12 g total fiber).
Also known as: Sugar beet, Pectin
38 g spray-dried oat drink, 30 g rye bran and 6 g sugar beet fiber were added to 250 ml blackcurrant beverage with pulp to give 5 g soluble fiber (18 g total fiber).
No fiber was added to control meal (250 g black-currant beverage)
Changed gene expression profile by fiber-rich meals
Time frame: 2 h after meal intake
Lowering of postprandial glucose by fiber-rich meals
Time frame: 0-180 min after meal intake
This study is completed, as verified in Oct 2009. You cannot join it, but the record below documents what was studied.
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