An observational study in Febrile, Neutropenia and Post-chemotherapy, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2012-07-26.
Sponsored by Assistance Publique - Hôpitaux de Paris · Observational
Febrile neutropenia are microbiologically documented in only 30% of the cases, and almost exclusively by blood cultures. The reasons for this low documentation are likely multiple: (1) some of these fevers are of non-infectious origin. (2) The bacterial inoculum present in the blood may be low and consequently undetectable by conventional blood cultures.
The primary objective of the study is to assess new blood culture procedures and technics, in order to improve the diagnostic yield of blood cultures during febrile neutropenic episodes.
Evaluation criteria are 1) proportion of microbiologically documented infections 2) time elapsed from bed side sampling to microbiological diagnostic, in case of positive sample.
The assessed procedures included a large volume of blood, an early incubation made possible by the availability of a culture device in the hematology department, an early warning in case of positive blood culture, bacterial DNA detection in blood, and an early identification of the positive strains and their resistance profile.
We hypothesize that the combination of these different procedures will improve the proportion of microbiologically blood culture from 30 to 45%. One hundred and 20 episodes of febrile neutropenia are necessary to achieve this goal.
396 studies on the registry are indexed under Neutropenia; 57 are open to participants now.
This study's enrollment of 120 is below the median of 175 across 96 observational studies indexed under Neutropenia.
Browse Neutropenia studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,506 studies on the registry; 1,007 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Febrile neutropenia post-chemotherapy
Exclusion Criteria:
febrile neutropenia patient
Other: sample blood
* Early culture * Bacterial DNA tests in blood
proportion of microbiologically documented infections
Time frame: Day 14 from inclusion
clinical status at the end of hospitalisation
Time frame: Day 30 from inclusion
This study is completed, as verified in Apr 2009. You cannot join it, but the record below documents what was studied.
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Assistance Publique - Hôpitaux de Paris