An interventional study of Apelin infusion and Sodium nitroprusside infusion in Heart Disease and Vasodilation, sponsored by University of Edinburgh. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-08-10.
Sponsored by University of Edinburgh · Not applicable, Interventional, and Basic science
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
Angiotensin has a powerful ability to cause blood vessels constrict and reduces their diameter. One of the actions of apelin is to cause blood vessels to relax and the investigators specifically wish test the hypothesis that apelin will cause blood vessels constricted by angiotensin II to relax.
3,674 studies on the registry are indexed under Heart Diseases; 458 are open to participants now.
This study's planned enrollment of 12 is below the median of 100 across 1,785 interventional studies indexed under Heart Diseases.
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Using forearm venous occlusion plethysmography angiotensin II will be infused to cause reduction in forearm blood flow. Infusion of apelin and sodium nitroprusside will given and vasodilatation will be assessed. Blood samples for the infused arm and contra-lateral arm will be taken at regular time points to assess local and systemic changes in relevant hormones.
Drug: Apelin infusion · Drug: Sodium nitroprusside infusion
Using forearm venous occlusion plethysmography noradrenaline will be infused to cause reduction in forearm blood flow. Infusion of apelin and sodium nitroprusside will given and vasodilatation will be assessed. Blood samples for the infused arm and contra-lateral arm will be taken at regular time points to assess local and systemic changes in relevant hormones.
Drug: Apelin infusion · Drug: Sodium nitroprusside infusion
Infusion of up to 10picmol/min will be administered intra-arterially to induce vasoconstriction. Thereafter infusions of apelin (0.1, 1.0, 3.0nmol/min) will be given for 6mins each. During the same study, sodium nitroprusside will given (1.0, 2.0, 4.0 microg/min) for 6mins.
Infusion of up to 150-600picmol/min will be administered intra-arterially to induce vasoconstriction. Thereafter infusions of apelin (0.1, 1.0, 3.0nmol/min) will be given for 6mins each. During the same study, sodium nitroprusside will given (1.0, 2.0, 4.0 microg/min) for 6mins.
Change in apelin mediated forearm blood flow
Time frame: 12 months
Change in local and systemic plasma apelin concentration in response angiotensin II infusion
Time frame: 12 months
The record gives a start of Apr 2009, a primary completion of May 2010 and a completion of May 2010. It does not say whether these dates are actual or estimated.
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This study is completed, as verified in Aug 2010. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Apelin