A Phase 4 interventional study of Prednisone in Chronic Sinusitis, Rhinosinusitis and Nasal Polyps, sponsored by Northwestern University. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-04-02.
Sponsored by Northwestern University · Phase 4, Interventional, and Treatment
This is a study to evaluate the cause of chronic sinus disease. Oral steroids have long been used in the treatment of inflammatory conditions including chronic sinusitis, asthma, and arthritis. However, it is not well known exactly which patients will benefit from steroids when used in the treatment of chronic sinusitis. For some doctors, it is common practice to use these medications prior to planned sinus surgery, to lessen the inflammation and possibly help the healing process. Other doctors feel oral steroids may not be helpful in this way, and there is no conclusive data as to whether this practice has a long term benefit.
The purpose of this research study is to better understand how this potential treatment option, oral steroids, affects biochemical substances that have been associated with the development of chronic sinusitis and polyps. In order to do this, we need to study people with different forms of chronic sinusitis and compare them to individuals without allergies or sinus disease. We will also look at patients with chronic sinusitis who are treated with oral steroids and compare them to chronic sinus patients who have not received oral steroid therapy prior to surgery. This study may help pave the way to new treatments that address specific parts of the chronic sinus inflammatory pathway.
Hypotheses
330 studies on the registry are indexed under Rhinosinusitis; 55 are open to participants now.
Browse Rhinosinusitis studies →Northwestern University is the lead sponsor of 1,420 studies on the registry; 199 are open to participants now.
Of its 103 completed or terminated interventional studies of FDA-regulated products, 75 (73%) have results posted.
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Exclusion Criteria:
Steroid medication
Drug: Prednisone
No Intervention
Prednisone 30mg once daily x 5 days
Also known as: Glucocorticoid, Deltasone, Liquid Pred, Meticorten, Orasone, Prednicen-M, Prednicot, Sterapred
Alterations of inflammatory cells, levels of key antibodies and cytokines, and expression of key epithelial genes
Time frame: Prior to surgery and steroid treatment and day of surgery w/ or w/o having been treated w/ steroids
This study is withdrawn, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Prednisone