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CompletedNCT00803998Updated Nov 1, 2013

Ocular Hypertension Treatment Study (OHTS)

An observational study in Ocular Hypertension and Glaucoma, sponsored by The New York Eye & Ear Infirmary. Completed. Open to participants aged 40 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-11-01.

Sponsored by The New York Eye & Ear Infirmary · Observational

Study type
Observational
Ages
40 Years to 80 Years
Sex
All
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Study summary

The Ocular Hypertension Treatment Study is a multi-center clinical trial sponsored by the National Eye Institute, designed to determine the efficacy and safety of topically administered eye lowering medication

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Conditions studied

  • Ocular Hypertension
  • Glaucoma
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In context

Ocular Hypertension

659 studies on the registry are indexed under Ocular Hypertension; 48 are open to participants now.

Browse Ocular Hypertension studies →

Lead sponsor

The New York Eye & Ear Infirmary is the lead sponsor of 22 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
40 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Qualifying IOP in at least one eye of each participant must be more than or equal 24 mmHg but less than or equal to 32 mm HG calculated from two separate consecutive determination taken at least 2 hours, but not greater than 12 weeks apart.
  • Normal and reliable 30-2 Humphrey Visual Fields in both eyes.
  • Normal Optic disc in both eyes on clinical examinations and stereoscopic photographs as determined by the Optic Disc Reading Center.

Exclusion criteria

Exclusion Criteria:

  • Visual acuity worse than 20/40 in either eye on qualifying exam.
  • Previous intraocular surgery: laser trabeculoplasty, laser iridotomy, filtering surgery, combined cataract extraction/filtering procedures, penetrating keratoplasty and retinal detachment repair.
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Study design

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Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Kass MA. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002 Jun;120(6):714-20; discussion 829-30. doi: 10.1001/archopht.120.6.714. PubMed 12049575 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 1, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00803998
Lead sponsor
The New York Eye & Ear Infirmary
First posted
Dec 8, 2008
Start date
Feb 1994
Completion
Dec 2006
Last update
Nov 1, 2013

Study contacts

Michael Kass, MD
study chair · Washington University School of Medicine at St. Louis, St. Louis, Missouri
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2008. You cannot join it, but the record below documents what was studied.

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Discussion

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