An interventional study of Exercise in Obesity, sponsored by Norwegian University of Science and Technology. Completed at 1 site in Norway. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-02-06.
Sponsored by Norwegian University of Science and Technology · Not applicable, Interventional, and Basic science
The identification and characterization of individuals who vary in their response to exercise-induced weight loss is important. Weight loss in response to exercise is variable and it remains unknown who will succeed, why, and more importantly how to improve weight loss efficacy.
This study will examine changes in behavioural, metabolic, physiological and biochemical variables in response to a 12 week supervised exercise programme and evaluate their association with weight loss in overweight and obese sedentary individuals.
Our hypothesis is that changes in the plasma levels of appetite related hormones undermine the inter individual variation in weight loss in response to exercise.
This study will improve the understanding of variability to exercise-induced weight loss and allow more individually tailored and appropriate strategies for weight management programmes.
Purpose - To identify predictors of weight loss in overweigh/obese volunteers following a 12 week supervised exercise programme, and to characterise the variability in weight loss response.
Method - Longitudinal study aiming to identify predictors of weight loss in response to a 12-week exercise programme in healthy overweight/obese volunteers.
Subjective and objective measures of appetite, cardiovascular fitness, anthropometry, body composition, resting metabolic rate (RMR), fat and carbohydrate oxidation in the fasting state will be measured at baseline, before participants enroll for the study and after the exercise intervention.
The preload/test-meal paradigm (using a high and low-energy preload: HEP vs LEP) will be used to assess short-term appetite control before and after the exercise intervention following a randomized single-blinded crossover design. Moreover, the long-term effects of exercise on cytokine plasma levels and fasting and postprandial levels of appetite related hormones/metabolites will also be assessed at baseline and end of the study. Participants will act as their own controls throughout the study.
1,766 studies on the registry are indexed under Weight Loss; 277 are open to participants now.
This study's enrollment of 22 is below the median of 73 across 1,496 interventional studies indexed under Weight Loss.
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Exclusion Criteria:
Behavioral: Exercise
12-week supervised exercise programme (5 times /week at 75% maximal Heart Rate)
Changes in fasting and postprandial plasma levels of appetite related hormones
Time frame: Baseline and after a 12 week exercise intervention
Changes in body weight and body composition
Time frame: Baseline and after a 12-week exercise intervention
This study is completed, as verified in Feb 2015. You cannot join it, but the record below documents what was studied.
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Norwegian University of Science and Technology