An interventional study of RBC transfusion of 5 days or less storage age and RBC transfusion of conventional storage age in Pulmonary Edemas and Blood Protein Disorders, sponsored by Mayo Clinic. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2012-01-31.
Sponsored by Mayo Clinic · Not applicable, Interventional, and Diagnostic
Specific aim: To test whether transfusion of leukoreduced red cells of lesser storage time (versus conventional storage time) reduces mild alterations in pulmonary function and immune activation in critically ill patients with mechanically ventilated lungs.
We propose to perform a prospective, randomized, double-blind clinical trial in critically ill patients whose lungs are mechanically ventilated, and who have orders to receive transfusion of at least one unit of packed red cells, comparing pulmonary function between patients randomly allocated to receive a unit of red cells stored for 5 days or less, with similar patients randomly allocated to receive a unit of red cells stored conventionally (median 21 days). We will test the hypothesis that transfusion of red cells of lesser storage age, (5 days or less) will produce the less changes of pulmonary function and immune activation than will transfusion of red cells of conventional storage age (median 21 days).
Specific aim: To test whether transfusion of leukoreduced red cells of lesser storage time (versus conventional storage time) reduces mild alterations in pulmonary function and immune activation in critically ill patients with mechanically ventilated lungs.
138 studies on the registry are indexed under Pulmonary Edema; 24 are open to participants now.
This study's enrollment of 100 is above the median of 68 across 72 interventional studies indexed under Pulmonary Edema.
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Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.
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Exclusion Criteria:
RBC transfusion of 5 days or less storage age
Other: RBC transfusion of 5 days or less storage age
RBC transfusion of conventional storage age
Other: RBC transfusion of conventional storage age
RBC transfusion of 5 days or less storage age
Also known as: RBC
RBC transfusion of conventional storage age
Also known as: RBC
We will test the hypothesis that the transfusion of red cells of lesser storage age, (5 days or less) will produce less changes of pulmonary function and immune activation than will transfusion of red cells of conventional storage age (median 21 days).
Time frame: At the end of the transfusion as compared to the beginning of the transfusion
This study is completed, as verified in Jan 2012. You cannot join it, but the record below documents what was studied.
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