CClinicalTrials.gg
CompletedNCT00657436MyRiADUpdated May 31, 2012

Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement

An observational study in Myocardial Ischemia, Acute Coronary Syndrome and Myocardial Infarction, sponsored by University of Zurich. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2012-05-31.

Sponsored by University of Zurich · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
403
Ages
18 Years to 90 Years
Sex
All
01

Study summary

The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk stratification in patients presenting with acute chest pain at the emergency department.

Study hypothesis: MRP 8/14, alone or together with other established or new biomarkers, increases the earliness, sensitivity, and specificity of diagnosing acute coronary syndromes.

02

Conditions studied

  • Myocardial Ischemia
  • Acute Coronary Syndrome
  • Myocardial Infarction
  • Coronary Occlusion
  • Coronary Thrombosis

Keywords

  • Acute Coronary Syndrome
  • Myocardial Infarction
  • Coronary Artery Disease
03

In context

Myocardial Infarction

2,744 studies on the registry are indexed under Myocardial Infarction; 418 are open to participants now.

This study's enrollment of 403 is below the median of 500 across 983 observational studies indexed under Myocardial Infarction.

Browse Myocardial Infarction studies →

Lead sponsor

University of Zurich is the lead sponsor of 1,030 studies on the registry; 130 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Consecutive patients - systematic sampling - presenting with acute chest pain at the emergency room in which determination of cardiac biomarkers is indicated for clinical diagnostics

Inclusion criteria

  • All patients in the emergency department of the University Hospital Zurich with measurement of troponin during the routine diagnostic evaluation.

Exclusion criteria

Exclusion Criteria:

  • Refusal or inability to give informed consent.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
403 participants (actual)
06

What researchers measure

Primary outcomes

  1. Diagnosis of acute coronary syndrome

    Time frame: Emergency room and/or hospital stay

Secondary outcomes

  1. Incidence of any acute coronary event

    Time frame: 1 year

  2. Morbidity from coronary artery disease

    Time frame: 1 year

  3. Mortality

    Time frame: 1 year

07

Study locations

1 site
  • Cardiology, University Hospital
    Zurich, 8091, Switzerland
08

References and documents

Publications

  • Altwegg LA, Neidhart M, Hersberger M, Muller S, Eberli FR, Corti R, Roffi M, Sutsch G, Gay S, von Eckardstein A, Wischnewsky MB, Luscher TF, Maier W. Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes. Eur Heart J. 2007 Apr;28(8):941-8. doi: 10.1093/eurheartj/ehm078. Epub 2007 Mar 26. PubMed 17387139 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 31, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00657436
Lead sponsor
University of Zurich
Collaborators
Swiss National Science Foundation
Responsible party
Sponsor
First posted
Apr 14, 2008
Start date
Mar 2008
Primary completion
Dec 2010
Completion
Dec 2010
Last update
May 31, 2012

Study contacts

Willibald Maier, MD
principal investigator · Cardiology, University Hospital Zurich

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2012. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion