An observational study in Viral Pneumonia and Bacterial Pneumonia, sponsored by University of Texas Southwestern Medical Center. Withdrawn at 1 site in United States. Open to participants aged Up to 18 Years. Per ClinicalTrials.gov, last updated 2018-12-26.
Sponsored by University of Texas Southwestern Medical Center · Observational
The purpose of this study is to determine whether a protein called TREM-1 can be used to differentiate viral and bacterial pneumonias in children who are on ventilator support. We propose that the level of TREM-1 will be significantly elevated in the lung fluid of children with bacterial pneumonia and viral with co-existing bacterial pneumonia than in children with pure viral pneumonia.
Most often, viruses are the cause of pneumonia in children. However, viral pneumonias are frequently associated with secondary bacterial pneumonia. It is important, though difficult, to differentiate patients who only have viral pneumonia from those who have viral pneumonia with secondary bacterial pneumonia. This will help physicians to prescribe antibiotics to only those with bacterial pneumonia and avoid antibiotic use in those with pure viral pneumonia, thus help to limit health-care cost and to decrease emergence of antibiotic resistance. In adult studies, TREM-1 has been shown to be specifically expressed in bacterial infections.
We propose that measuring TREM-1 in the bronchoalveolar lavage (BAL) fluid will help to differentiate these groups. Our hypothesis is that concentration of TREM-1 will be significantly elevated in the BAL fluid of children with bacterial pneumonia and viral with co-existing bacterial pneumonia than in children with pure viral pneumonia.
2,044 studies on the registry are indexed under Pneumonia; 283 are open to participants now.
Browse Pneumonia studies →University of Texas Southwestern Medical Center is the lead sponsor of 990 studies on the registry; 201 are open to participants now.
Of its 135 completed or terminated interventional studies of FDA-regulated products, 100 (74%) have results posted.
Counted across the registry records on this site, refreshed daily.
Intubated patients in the intensive care unit with respiratory failure. Intubated patients patients in the OR undergoing video-assisted thoracic surgery for empyema.
Intubated patients undergoing cardiopulmonary bypass.
Exclusion Criteria:
Patients with pure viral pneumonia
Patients with viral pneumonia along with secondary bacterial pneumonia
Patients with significant bacterial pneumonia
Patients with congenital heart disease undergoing cardiopulmonary bypass who have no pneumonia
TREM-1 level in the BAL fluid of patients with pure viral pneumonia in comparison to patients with viral with co-existing bacterial pneumonia
Time frame: Within 48 hours of being intubated
TREM-1 level in the BAL fluid of patients with pure bacterial pneumonia and no pneumonia
Time frame: Within 48 hours of intubation for TREM-1 level
TREM-1 level in the serum of all 4 groups
Time frame: Within 48 hours of intubation for TREM-1 level
Length of ventilator support, length of ICU and hospital stay
Time frame: Within 48 hours of intubation for TREM-1 level
This study is withdrawn, as verified in Dec 2018. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Texas Southwestern Medical Center