An interventional study of cytokine and cytokine polymorphisms in Fibrosis and Chronic Liver Disease, sponsored by Kaohsiung Medical University Chung-Ho Memorial Hospital. Completed at 2 sites in Taiwan. Per ClinicalTrials.gov, last updated 2013-04-18.
Sponsored by Kaohsiung Medical University Chung-Ho Memorial Hospital · Not applicable, Interventional, and Basic science
Hepatitis C virus (HCV) infection causes different disease spectrum ranging from minimal progressive liver disease to cirrhosis or hepatocellular carcinoma. Evidence indicates that host genetic factor may play a role in determining disease progression. It is known that many cytokine polymorphisms affect disease progressin via increasing hepatic fibrosis that are key factors in progressing liver injury. By combinations of fibrosis-relating gene polymorphisms, this study aims to identify patients with high risk for progressive liver disease. These patients need intensive therapy to decrease morbidity and mortality of chronic HCV-related liver disease.
Determination of the following fibrosis-relating gene polymorphisms in HCV-related chronic liver disease and HCC will be performed: TNF-α , TNF-β, Factor V Leiden, TGF-β1, PDGF-B gene, Angiotensinogen (AT),Angiotensin converting enzyme (ACE), microsomal epoxide hydrolase (mEH) and glutathione-S-transferase (GST).
2,081 studies on the registry are indexed under Liver Diseases; 390 are open to participants now.
This study's enrollment of 600 is above the median of 50 across 1,323 interventional studies indexed under Liver Diseases.
Browse Liver Diseases studies →Kaohsiung Medical University Chung-Ho Memorial Hospital is the lead sponsor of 281 studies on the registry; 57 are open to participants now.
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Exclusion Criteria:
Relate the fibrosis cytokine gene polymorphisms with disease severity of HCV-related chronic liver disease
Genetic: cytokine · Genetic: cytokine polymorphisms · Genetic: cytokine polymorphism
polymorphisms of fibrosis-relating cytokine were measured to validate the effectiveness of fibrosis in HCV-related chronic liver disease
Also known as: hepatitis C virus infection, cytokine polymorphism, fibrosis
Fibrosis-relating cytokine polymorphisms in hepatitis C virus-related chronic liver disease were measured to validate the degree of fibrosis
Also known as: hepatitis C virus infection, cytokine polymorphism, fibrosis
fibrosis-relating cytokine polymorphism
Also known as: hepatitis C virus infection, cytoline polymorphism, fibrosis
cytokine gene polymorphism on disease severity
Time frame: years
This study is completed, as verified in Apr 2013. You cannot join it, but the record below documents what was studied.
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Kaohsiung Medical University Chung-Ho Memorial Hospital