An interventional study of Inderol (propranolol) in Posttraumatic Stress Disorders, sponsored by Kent State University. Completed. Open to participants aged 10 Years to 18 Years. Per ClinicalTrials.gov, last updated 2008-01-18.
Sponsored by Kent State University · Not applicable, Interventional, and Prevention
Twenty-nine pediatric injury patients (ages 10-18) at risk for PTSD were randomly assigned to receive either propranolol or placebo in a double-blind placebo controlled design. Medication was initiated within 12 hours of hospital admission. At 6-weeks, child PTSD symptoms and heart rate (HR) during trauma recall were assessed. We hypothesized that participants who received propranolol would report fewer PTSD symptoms and have lower heart rates than those who received placebo.
1,147 studies on the registry are indexed under Stress Disorders, Traumatic; 108 are open to participants now.
This study's enrollment of 29 is below the median of 60 across 908 interventional studies indexed under Stress Disorders, Traumatic.
Browse Stress Disorders, Traumatic studies →Kent State University is the lead sponsor of 31 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
oral solution of propranolol (propranolol HCL 20 mg/5 ml solution) or a liquid placebo twice daily for 10 days (and taper for 5 days; based on Pitman et al, 2002). Dose was calculated as determined by Famularo et al. (1988) to be 2.5 mg/kg/d with a maximum dose of 40 mg bid (Green, 2001).
Drug: Inderol (propranolol)
A 25/5ml solution of placebo (a sugar solution that looks and tastes like the propranolol solution)
Drug: Inderol (propranolol)
Children ingested a propranolol HCL 20 mg/5 ml solution twice daily for 10 days (and taper for 5 days). Medication was initiated within 12 hours post-trauma. Dose was calculated to be 2.5 mg/kg/d with a maximum dose of 40 mg.
Also known as: propranolol
PTSD symptoms with the Clinician Administered PTSD Scale for Children and Adolescents (CAPS-CA)
Time frame: 6-week follow-up
cardiovascular reactivity during trauma description
Time frame: at 6-week follow-up
No study locations are listed for this record.
This study is completed, as verified in Jan 2008. You cannot join it, but the record below documents what was studied.
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Kent State University