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CompletedNCT00546182Updated Oct 18, 2007

Simvastatin Reduces Adiponectin Levels and Insulin Sensitivity

An observational study in Hypercholesterolemia, sponsored by Gachon University Gil Medical Center. Completed at 1 site in Korea, Republic of. Open to participants aged 25 Years to 75 Years. Per ClinicalTrials.gov, last updated 2007-10-18.

Sponsored by Gachon University Gil Medical Center · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Ages
25 Years to 75 Years
Sex
All
01

Study summary

We hypothesized simvastatin may reduce adiponectin levels and insulin sensitivity in overweight hypercholesterolemic patients.

02

Conditions studied

  • Hypercholesterolemia

Keywords

  • Lipophilic statins
  • Insulin resistance
  • hypercholesterolemic patients
03

In context

Hypercholesterolemia

1,238 studies on the registry are indexed under Hypercholesterolemia; 110 are open to participants now.

Browse Hypercholesterolemia studies →

Lead sponsor

Gachon University Gil Medical Center is the lead sponsor of 88 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
25 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Study population

overweight hypercholesterolemic patients

Inclusion criteria

  • Low-density lipoprotein cholesterol levels more than 100 and body mass index more than 23.0

Exclusion criteria

Exclusion Criteria:

  • Patients with overt liver disease
  • Chronic renal failure
  • Hypothyroidism, myopathy
  • Uncontrolled diabetes
  • Severe hypertension, stroke
  • Acute coronary events
  • Coronary revascularization within the preceding 3 months, or
  • Alcohol abuse.
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Study design

Observational model
Case-control
Time perspective
Prospective
06

What researchers measure

Primary outcomes

  1. simvastatin may reduce adiponectin levels and insulin sensitivity in overweight hypercholesterolemic patients

07

Study locations

1 site
  • Gil Medical Center, Gachon University
    Incheon, 405760, Korea, Republic of
08

References and documents

Publications

  • Yada T, Nakata M, Shiraishi T, Kakei M. Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. Br J Pharmacol. 1999 Mar;126(5):1205-13. doi: 10.1038/sj.bjp.0702397. PubMed 10205010 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 18, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00546182
Lead sponsor
Gachon University Gil Medical Center
First posted
Oct 18, 2007
Start date
Jan 2004
Last update
Oct 18, 2007

Study contacts

Kwang K Koh, MD,PhD
principal investigator · Gachon University Gil Medical Center

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2007. You cannot join it, but the record below documents what was studied.

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