An interventional study of propofol concentration in Igel, sponsored by Gachon University Gil Medical Center. Completed. Open to participants aged 20 Years to 60 Years. Per ClinicalTrials.gov, last updated 2022-08-03.
Sponsored by Gachon University Gil Medical Center · Not applicable, Interventional, and Prevention
Before anethetic induction, infuse dexmedetomidine 0.5 mcg/kg for 2 minutes and after injection of lidocaine 30 mg, propofol infusion by using target controlled infusion (TCI) pump. Effect site concentraion of propofol start from 5 and changes the concentration as previous response to i-gel insertion as up and down methods
Before anethetic induction, infuse dexmedetomidine 0.5 mcg/kg for 2 minutes and after injection of lidocaine 30 mg, propofol infusion by using target controlled infusion (TCI) pump. Effect site concentraion of propofol start from 5 and changes the concentration as previous response to i-gel insertion as up and down methods. Failure of previous subjects are defined as difficulty to mouth open, severe nausea and couph and laryngeal spasm, and not loss of consciousness.
Gachon University Gil Medical Center is the lead sponsor of 90 studies on the registry; 3 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
after infusion of dexmedetomidine dexmedetomidine 0.5 mcg/kgfor 2 min, infusion of propofol as using target controlled infusion pump. Effect site concentration would be changed as the response to i-gel insertion as up and down method in male
Drug: propofol concentration
after infusion of dexmedetomidine dexmedetomidine 0.5 mcg/kgfor 2 min, infusion of propofol as using target controlled infusion pump. Effect site concentration would be changed as the response to i-gel insertion as up and down method in female
Drug: propofol concentration
First subjects start from effect site concentraion of 5ug/ml propofol, after insertion of i-gel, determine the next subjects' effect site concentraion would be increae or decrease 0.5 ug/ml as up and down method
Also known as: up and down method
Concentration of Propofol
effect site concentration of propofol
Time frame: from i-gel insertion up to 5 min
| Milestone | Concentration of Propofol in Male | Concentraion of Propofol Infemale |
|---|---|---|
| Started | 20 | 20 |
| Completed | 20 | 20 |
| Not completed | 0 | 0 |
effect site concentration of propofol
| ug/ml | Concentration in Male | Concentraion in Female |
|---|---|---|
| Concentration of Propofol | 5.46 ± 0.26 | 3.82 ± 0.34 |
Collected over During administration of study drugs approximately 5 minutes. Non-serious events are listed at a 5% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Concentration in Male | 0/20 (0%) | 0/20 (0%) | 1/20 (5%) |
| Concentraion in Female | 0/20 (0%) | 0/20 (0%) | 1/20 (5%) |
| Event | Concentration in Male | Concentraion in Female |
|---|---|---|
| bradycardiaGeneral disorders | 1/20 | 0/20 |
| hypertensionGeneral disorders | 0/20 | 1/20 |
| Age, Continuous(years) | Concentration in Male | Concentraion in Female | Total |
|---|---|---|---|
| Mean | 35 ± 11 | 35 ± 9 | 35 ± 10 |
| Sex: Female, Male(Participants) | Concentration in Male | Concentraion in Female | Total |
|---|---|---|---|
| Female | 0 | 20 | 20 |
| Male | 20 | 0 | 20 |
| Region of Enrollment(participants) | Concentration in Male | Concentraion in Female | Total |
|---|---|---|---|
| South Korea | 20 | 20 | 40 |
No study locations are listed for this record.
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Ige Responsiveness, Atopic
Gachon University Gil Medical Center