A Phase 1 interventional study of simvastatin in Hypertension, Pulmonary, sponsored by Capital Medical University. Status unknown at 1 site in China. Open to participants aged 12 Years to 70 Years. Per ClinicalTrials.gov, last updated 2007-10-02.
Sponsored by Capital Medical University · Phase 1, Interventional, and Treatment
we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.
advanced pulmonary hypertension is refractory to the medication in use nowaday, especially pulmonary hypertension secondary to congenital heart disease or chronic pulmonary embolism.It is revealed that statins may intefere the pathogenisis of the pulmonary hypertension in many key poing, such as improving apotosis or inhiting the proliferation of pulmonary vascular smooth muscle cell. so we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.
1,105 studies on the registry are indexed under Hypertension, Pulmonary; 234 are open to participants now.
Browse Hypertension, Pulmonary studies →Capital Medical University is the lead sponsor of 283 studies on the registry; 92 are open to participants now.
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before the operation, the patient start the simvastatin medication on the dosage of 40mg per day
Drug: simvastatin
just do routin operation with no use of simvastatin, other medication is exact the same as the simvastatin group
medication with simvastation on the dosage of 40mg per day before the operation and all the time after the operation
the simvastatin can alleviate pulmonary hypertension
pulmonary pressure
simvastatin can highten the perioperative and long term survaval rate and the living quality
This study is status unknown, as verified in Sep 2007. You cannot join it, but the record below documents what was studied.
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Capital Medical University