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TerminatedNCT00488670Updated Jun 6, 2011

Escitalopram and Depression in Elderly Alzheimer's Patients

A Phase 3 interventional study of Escitalopram in Depressive Disorder, sponsored by University of British Columbia. Terminated at 2 sites in Canada. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2011-06-06.

Sponsored by University of British Columbia · Phase 3, Interventional, and Treatment

Why this study was terminated
Dr. Rabheru left VCH last year and the study was cancelled according to his research coordinator.
Phase
Phase 3
Study type
Interventional
Enrollment
50
Allocation
Non-randomized
Ages
50 Years and older
Sex
All
01

Study summary

To investigate the effect of Escitalopram in a large and diverse of dementia patients suffering from depression.

Read the detailed description

This study will assess the efficacy, tolerability, and safety of escitalopram in the treatment of Major Depressive Disorder in patients with Alzheimer's disease over a 24-week period. It will also assess the efficacy and tolerability of escitalopram after 12 weeks of treatment.

02

Conditions studied

  • Depressive Disorder

Keywords

  • Alzheimer's disease
  • elderly
  • open-label
  • escitalopram
03

In context

Depressive Disorder

4,845 studies on the registry are indexed under Depressive Disorder; 514 are open to participants now.

This study's planned enrollment of 50 is below the median of 80 across 3,999 interventional studies indexed under Depressive Disorder.

Browse Depressive Disorder studies →

Lead sponsor

University of British Columbia is the lead sponsor of 1,309 studies on the registry; 253 are open to participants now.

Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
50 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Inclusion Criteria:

  • > 50 years
  • Male \& female
  • Alzheimer's disease
  • Depressive episode
05

Study design

Phase
Phase 3
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
50 participants (estimated)

Interventions

  • DrugEscitalopram

    See Detailed Description.

06

What researchers measure

Primary outcomes

  1. Change in Cornell Scale for Depression in Dementia (CSDD) from baseline.

Secondary outcomes

  1. Montgomery-Åsberg Depression Rating Scale; Neuropsychiatric Inventory; Alzheimer's Disease Cooperative Study

07

Study locations

2 sites
  • Mt. St. Joseph's Hospital
    Vancouver, British Columbia, Canada
  • Vancouver General Hospital
    Vancouver, British Columbia, Canada
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 6, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00488670
Lead sponsor
University of British Columbia
First posted
Jun 20, 2007
Start date
Dec 2010
Primary completion
Jun 2011
Completion
Jun 2011
Last update
Jun 6, 2011

Study contacts

Kiran Rabheru, MD
principal investigator · University of British Columbia

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Jun 2011. You cannot join it, but the record below documents what was studied.

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