A Phase 4 interventional study of Sevoflurane and propofol in Coronary Artery Disease and Off Pump Coronary Artery Bypass Surgery, sponsored by University Hospital Dubrava. Completed at 1 site in Croatia. Open to participants aged 40 Years to 75 Years. Per ClinicalTrials.gov, last updated 2007-05-24.
Sponsored by University Hospital Dubrava · Phase 4, Interventional, and Treatment
In vitro studies and in vivo animal experiments have shown that halogenated volatile anesthetics have a protective effect on the ischemic myocardium. In clinical settings however, anesthetic preconditioning may be of more interest. The aim of our study was to evaluate the cardioprotective effect of sevoflurane in patients undergoing off-pump coronary artery bypass surgery. We proposed that a cardioprotective effect of sevoflurane would save myocardial function, which we measured acceleration by esophageal Doppler and cardiac index with bolus thermodilution methods, both during brief ischemia and reperfusion.
Studies have been performed on human patients undergoing CABG surgery with cardiopulmonary bypass (CPB). Only a few studies however have evaluated the effects of volatile anesthetics during coronary artery bypass grafting on a beating heart (OPCABG) with conflicting results as far as cardiac biomarker release is concerned.
Because CPB is known to have a profound impact on cardiac function, studies performed on patients scheduled for OPCABG could evaluate more specifically the effects of the anesthetic agents themselves. Patients undergoing OPCABG have a predictable and predefined ischemic zone during surgery and represent an extremely interesting and safe model for the study of ischemia and cardiac damage in humans.
Presently, there is still no consensus on the method of administration of volatile anesthetics, including the time to begin administration, its duration, the dosage and selection of volatile anesthetics.
5,676 studies on the registry are indexed under Coronary Artery Disease; 958 are open to participants now.
This study's enrollment of 32 is below the median of 123 across 3,481 interventional studies indexed under Coronary Artery Disease.
Browse Coronary Artery Disease studies →University Hospital Dubrava is the lead sponsor of 42 studies on the registry; 11 are open to participants now.
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To evaluate cardiac function with measuring of hemodynamic parameters
Time frame: Measurements were performed at the following intervals: 5 minutes after anesthesia induction; at the beginning of ischemia; 15 minutes after ischemia; 15 minutes after sternum closure
This study is completed, as verified in May 2007. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Sevoflurane
University Hospital Dubrava