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CompletedNCT00462319ARTISTUpdated Apr 19, 2007

ARTIST: ARThrose Intervention STandardisée

A Phase 4 interventional study of Education, weight reduction and physical exercise in Knee Osteoarthritis, sponsored by Almirall, SAS. Completed at 1 site in France. Open to participants aged 45 Years to 75 Years. Per ClinicalTrials.gov, last updated 2007-04-19.

Sponsored by Almirall, SAS · Phase 4, Interventional, and Educational/counseling/training

Phase
Phase 4
Study type
Interventional
Allocation
Randomized
Ages
45 Years to 75 Years
Sex
All
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Study summary

International recommendations (ACR,EULAR) emphasize physical exercise and weight loss for patients suffering from knee osteoarthritis. Nevertheless, number of patients receiving advices for these 2 points still low. This study evaluates the impact of a standardized medical intervention (patient education, weight reduction and physical exercise) in knee osteoarthritis patients.

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Conditions studied

  • Knee Osteoarthritis
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In context

Osteoarthritis

4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.

Browse Osteoarthritis studies →

Lead sponsor

This is the only study on the registry with Almirall, SAS as lead sponsor.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
45 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • symptomatic and ambulatory patients
  • suffering from knee osteoarthritis (ACR criteria)
  • 25\<BMI\<35
  • signed informed consent

Exclusion criteria

Exclusion Criteria:

  • need to surgery within 6 next months
  • co-morbidity
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Study design

Phase
Phase 4
Primary purpose
Educational/counseling/training
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)

Interventions

  • BehavioralEducation, weight reduction and physical exercise
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What researchers measure

Primary outcomes

  1. Weight

  2. Physical Exercise in Leisure

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Study locations

1 site
  • Paris, France
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References and documents

Publications

  • Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 2000 Sep;43(9):1905-15. doi: 10.1002/1529-0131(200009)43:93.0.CO;2-P. No abstract available. PubMed 11014340 ↗
  • Messier SP, Gutekunst DJ, Davis C, DeVita P. Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum. 2005 Jul;52(7):2026-32. doi: 10.1002/art.21139. PubMed 15986358 ↗
  • Ravaud P, Flipo RM, Boutron I, Roy C, Mahmoudi A, Giraudeau B, Pham T. ARTIST (osteoarthritis intervention standardized) study of standardised consultation versus usual care for patients with osteoarthritis of the knee in primary care in France: pragmatic randomised controlled trial. BMJ. 2009 Feb 23;338:b421. doi: 10.1136/bmj.b421. PubMed 19237406 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 19, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00462319
Lead sponsor
Almirall, SAS
First posted
Apr 19, 2007
Start date
May 2005
Last update
Apr 19, 2007

Study contacts

René Marc FLIPO
principal investigator · Hôpital Salengro - Lille, France

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2007. You cannot join it, but the record below documents what was studied.

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