CClinicalTrials.gg
CompletedNCT00453726Updated Oct 5, 2009

Brain Natriuretic Peptide (BNP) Levels in Patients in Non Invasive Mechanical Ventilation

An observational study in Respiratory Insufficiency, sponsored by Ospedale S. Giovanni Bosco. Completed at 1 site in Italy. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2009-10-05.

Sponsored by Ospedale S. Giovanni Bosco · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
40
Ages
18 Years to 90 Years
Sex
All
01

Study summary

The purpose of the study is to evaluate variation of BNP in non invasive mechanical ventilated patients with severe acute respiratory failure.

Read the detailed description

The aim of the study is to evaluate in patients with severe acute respiratory failure requiring non invasive mechanical ventilation BNP levels at admission and during the following 24 hours during non invasive mechanical ventilation (Non Invasive Positive Pressure Ventilation or Continuous positive airway pressure).

Because in patients affected by acute respiratory failure it is often difficult to distinguish if the disease precipitating the respiratory failure is a cardiac disease or a lung disease, aim of the present study is to evaluate the discriminating role that BNP could have in this group of patients; evaluation will be completed, once obtained clinical stabilisation, with an echocardiography and respiratory functional test.

02

Conditions studied

  • Respiratory Insufficiency

Keywords

  • Natriuretic peptide brain
  • Continuous positive airway pressure
  • Intermittent positive pressure breathing
  • Respiratory insufficiency
03

In context

Respiratory Insufficiency

1,650 studies on the registry are indexed under Respiratory Insufficiency; 296 are open to participants now.

This study's planned enrollment of 40 is below the median of 100 across 545 observational studies indexed under Respiratory Insufficiency.

Browse Respiratory Insufficiency studies →

Lead sponsor

Ospedale S. Giovanni Bosco is the lead sponsor of 7 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients of the city of Torino, admitted to the emergency department for acute respiratory failure.

Inclusion criteria

  • Severe respiratory distress (use of respiratory accessory muscles);
  • Respiratory rate > 25 per minute;
  • Respiratory acidosis (pH \< 7.35 and PaCO2 > 45 mmHg);
  • PaO2/FiO2 \< 250

Exclusion criteria

Exclusion Criteria:

  • Age \< 18 years;
  • Facial deformities;
  • Pneumothorax;
  • Shock or systolic arterial pressure below 90 mmHg with amine infusion;
  • Life-threatening arrhythmias;
  • Need for immediate endotracheal intubation (PaO2/FiO2 \< 100 with FiO2 100%, respiratory rate \< 10, GCS \< 8);
  • Lack of co-operation from the patient;
  • Recent esophageal-gastric surgery;
  • Inability to clear secretions;
  • Drugs that may interfere with BNP secretion;
  • Severe obesity;
  • Hepatic cirrhosis with ascitis;
  • Endocrine disease.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
40 participants (estimated)

Interventions

  • ProcedureNon invasive mechanical ventilation
06

Study locations

1 site
  • Ospedale San Giovanni Bosco Medicina d'Urgenza
    Torino, Piedmont 10154, Italy
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 5, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT00453726
Lead sponsor
Ospedale S. Giovanni Bosco
First posted
Mar 29, 2007
Start date
May 2006
Completion
Jul 2009
Last update
Oct 5, 2009

Study contacts

Giovanni Ferrari, MD
principal investigator · Ospedale San Giovanni Bosco ASL4 Torino Italy

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2009. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion