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CompletedNCT00449943Updated Jan 26, 2012

Comparison of Cardiac Computed Tomographic Angiography (CTA) to Tc-99m Single Photon Emission Computed Tomography (SPECT)

An interventional study of Computed Tomographic Angiography and Myocardial Perfusion Imaging Scan in Coronary Artery Disease, sponsored by Ottawa Heart Institute Research Corporation. Completed at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2012-01-26.

Sponsored by Ottawa Heart Institute Research Corporation · Not applicable, Interventional, and Diagnostic

Phase
Not applicable
Study type
Interventional
Enrollment
107
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

Cardiovascular disease and ischemic heart disease is the #1 killer in Canada. Currently, Cardiac invasive catheterization angiography (CICA) is the gold standard for the assessment of the arteries in the heart. However, cardiac catheterization has risks which prohibit its use in all patients. These risks include: death, heart attack, stroke and bleeding. Cardiac computed tomography angiography (CTA) is a new non-invasive technology which may enable the evaluation of patients' coronary anatomy without exposing patients to the risks of invasive cardiac catheterization.

The purpose of this project is to compare CT angiography (CTA) to Tc-99m single photon emission computed tomography (Tc-99m SPECT)

We will enroll patients who are waiting for a CICA or who have been referred for a TC-99m SPECT or CTA scans at the University of Ottawa Heart Institute. Consenting patients who are waiting for a CICA will have both a CTA and a Tc-99m SPECT scan. Consenting patients referred for a CTA or Tc-99m SPECT will have both the CTA and Tc-99m SPECT in a random order but not CICA (unless ordered by your physician).

02

Conditions studied

  • Coronary Artery Disease

Keywords

  • Cardiac Invasive Catheterization Angiography
  • Single Photon Emission Computed Tomography
  • Computed Tomography Angiography
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In context

Coronary Artery Disease

5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.

This study's enrollment of 107 is below the median of 124 across 3,436 interventional studies indexed under Coronary Artery Disease.

Browse Coronary Artery Disease studies →

Lead sponsor

Ottawa Heart Institute Research Corporation is the lead sponsor of 179 studies on the registry; 41 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patients referred for Tc-99m SPECT or CTA; or
  • Patients referred for CICA without preceding (\< 12 months) MPI or CTA

Exclusion criteria

Exclusion Criteria:

  • Previous revascularization (PCI or CABG)
  • Age \< 18 years or lack of consent
  • Renal Insufficiency (GFR \< 60 ml/min)
  • Allergy or contraindication to contrast agent or dipyridamole
  • Refractory angina requiring urgent/emergent coronary angiography
  • Contraindication to radiation exposure (e.g. pregnancy)
  • Uncontrolled HR
  • Atrial fibrillation, frequent atrial or ventricular ectopy (> 1/minute)
  • Unable to perform 10 second breath-hold
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Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Non-randomized
Intervention model
Single group
Masking
Single (Outcomes assessor)
Enrollment
107 participants (actual)

Interventions

  • ProcedureComputed Tomographic Angiography

    CT scan

  • ProcedureMyocardial Perfusion Imaging Scan

    SPECT

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What researchers measure

Primary outcomes

  1. To measure the accuracy of CTA to SPECT for the diagnosis of CAD

    Time frame: 1 year

Secondary outcomes

  1. To examine the accuracy of CTA predicting the mode of treatment: Medical therapy or revascularization (PCI versus CABG)

    Time frame: 1 year

07

Study locations

1 site
  • University of Ottawa Heart Institute
    Ottawa, Ontario K1Y 4W7, Canada
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References and documents

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 26, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00449943
Lead sponsor
Ottawa Heart Institute Research Corporation
Responsible party
Benjamin Chow (MD, Ottawa Heart Institute Research Corporation) — Principal investigator
First posted
Mar 21, 2007
Start date
Sep 2006
Primary completion
Dec 2008
Completion
Dec 2010
Last update
Jan 26, 2012

Study contacts

Benjamin JW Chow, MD, FRCPC
principal investigator · Ottawa Heart Institute Research Corporation
Robert Beanlands, MD
study chair · Ottawa Heart Institute Research Corporation
Terrence Ruddy, MD
study chair · Univeristy of Ottawa Heart Institute
Carole Dennie, MD
study chair · The Ottawa Hospital
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2012. You cannot join it, but the record below documents what was studied.

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