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CompletedNCT00443716Updated Jan 15, 2010

Determination of Adipocyte Parameters in Iliac Crest Biopsies From Post Menopausal Women

An interventional study of estrogen in Osteoporosis and Postmenopausal, sponsored by Mayo Clinic. Completed at 1 site in United States. Open to female participants aged 30 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-01-15.

Sponsored by Mayo Clinic · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
30 Years and older
Sex
Female
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Study summary

To evaluate the effect of estrogen treatment on adipocytic and osteoblastic parameters by histomorphometrically measuring adipocyte volume (AV/TV) and adipocyte numbers in goldner's stained iliac crest bone biopsy specimens collected from subjects recruited in the study (IRB number 21B85). The adipocytic parameters will be then correlated with osteoblastic parameters obtained previously during the course of the initai study involving the effect of transdermal estrogen on bone turnover in postmenopausal osteoporotic women.

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Conditions studied

  • Osteoporosis
  • Postmenopausal

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03

In context

Osteoporosis

1,640 studies on the registry are indexed under Osteoporosis; 212 are open to participants now.

This study's enrollment of 60 is below the median of 95 across 1,133 interventional studies indexed under Osteoporosis.

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Lead sponsor

Mayo Clinic is the lead sponsor of 3,218 studies on the registry; 670 are open to participants now.

Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
30 Years and older
Sexes eligible
Female
Accepts healthy volunteers
Yes

Eligibility criteria

Post-menopausal osteoporotic women

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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
60 participants

Interventions

  • Drugestrogen
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What researchers measure

Primary outcomes

  1. efficacy of estraderm treatment on osteoporotic women

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Study locations

1 site
  • Mayo Clinic
    Rochester, Minnesota 55905, United States
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 15, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00443716
Lead sponsor
Mayo Clinic
First posted
Mar 6, 2007
Start date
Apr 1985
Primary completion
Apr 1989
Completion
Apr 1989
Last update
Jan 15, 2010

Study contacts

B. Lawrence Riggs, M.D.
principal investigator · Mayo Clinic

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2010. You cannot join it, but the record below documents what was studied.

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