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CompletedNCT00424957Updated Feb 5, 2009

Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System

An observational study in Cirrhosis and Hepatic Encephalopathy, sponsored by University of Aarhus. Completed at 1 site in Denmark. Open to participants aged 45 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-02-05.

Sponsored by University of Aarhus · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
18
Ages
45 Years to 65 Years
Sex
All
01

Study summary

The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.

02

Conditions studied

  • Cirrhosis
  • Hepatic Encephalopathy

Keywords

  • Ammonia
  • Astrocytes
  • Citric acid cycle
  • Alpha ketoglutarate dehydrogenase
03

In context

Hepatic Encephalopathy

218 studies on the registry are indexed under Hepatic Encephalopathy; 48 are open to participants now.

This study's planned enrollment of 18 is below the median of 100 across 56 observational studies indexed under Hepatic Encephalopathy.

Browse Hepatic Encephalopathy studies →

Lead sponsor

University of Aarhus is the lead sponsor of 1,274 studies on the registry; 183 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
45 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy, 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy, 6 healthy subjects age and sex matched

Inclusion criteria

  • 6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy,
  • 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy,
  • 6 healthy subjects age and sex matched

Exclusion criteria

Exclusion Criteria:

  • Neurological and/or psychiatric condition,
  • Non-treated diabetes,
  • Pregnancy/breast-feeding
05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
18 participants (estimated)
06

Study locations

1 site
  • PET Centre, Aarhus University Hospital
    Aarhus, 8000, Denmark
07

References and documents

Publications

  • Ott P, Clemmesen O, Larsen FS. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis. Neurochem Int. 2005 Jul;47(1-2):13-8. doi: 10.1016/j.neuint.2005.04.002. PubMed 15921824 ↗
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 5, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00424957
Lead sponsor
University of Aarhus
First posted
Jan 22, 2007
Start date
Nov 2006
Primary completion
Apr 2007
Completion
Oct 2008
Last update
Feb 5, 2009

Study contacts

Susanne Keiding, MD
study chair · PET Centre and Medical department V, Aarhus Sygehus, Aarhus University Hospital

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2009. You cannot join it, but the record below documents what was studied.

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